Fourier analysis versus multiple linear regression to analyse pressure-flow data during artificial ventilation

Peslin, R; Gallina, C.; Saunier, C; Duvivier, C.

doi:10.1183/09031936.94.07122241

Cited by 12 publications

(7 citation statements)

References 12 publications

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“…If the flow has an offset, then the calculation of compliance and resistance with the regression method may be imperfect (12). Furthermore, this flow offset can…”

Section: Discussionmentioning

confidence: 99%

Leak measurements in spontaneously breathing premature newborns by using the flow-through technique

Foitzik

Schmidt

Windstetter

et al. 1998

Journal of Applied Physiology

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A new method for measuring and correcting air leaks during lung-function testing in infants has been validated in vitro and in vivo by using a flow-through system that measured the inflow and outflow of a face mask. An adjustable leak was quantified by using suction flow to validate the accuracy of leak measurements. To validate the leak correction, the volume of a pump was measured with different air leaks (0-30%). The method developed was tested in 67 infants breathing spontaneously. There was good agreement between measured and simulated leaks (r = 0.998, P < 0.001; 95% limits of agreement were -0.3 and 0.1%, respectively). The volume was generally underestimated because of leaks, and the volume error was up to 94% compared with the maximum error of 5% after leak correction. With continuous leak measurements in vivo, there were <4% actual leaks (median 2.6%), and we did not observe any leaks in >7% of cases. The leak correction improved the accuracy of ventilatory measurements. The monitoring of leaks is helpful for airtight placement of the face mask and for prevention of serious measurement errors caused by leaks.

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“…If the flow has an offset, then the calculation of compliance and resistance with the regression method may be imperfect (12). Furthermore, this flow offset can…”

Section: Discussionmentioning

confidence: 99%

Leak measurements in spontaneously breathing premature newborns by using the flow-through technique

Foitzik

Schmidt

Windstetter

et al. 1998

Journal of Applied Physiology

View full text Add to dashboard Cite

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“…An important advantage of LRA is the synchronous evaluation of its reliability according to the standard error of estimation, corresponding to the Root Mean Square Difference. In most cases of MV the RMSD has been proved satisfactory, according to previous studies [37,48] Therefore, the use of LRA may disregard important dependences of respiratory mechanics on volume and flow. These non-linearities have been recognized in previous studies.…”

Section: Discussionmentioning

confidence: 73%

Non-interventional monitoring of expiratory flow limitation during experimental mechanical ventilation

et al. 2020

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BackgroundΕxpiratory flow limitation (EFL) is common among ICU patients under mechanical ventilation (MV) and may have significant clinical consequences. In the present study, we examine the possibility of non-interventional detection of EFL during experimental MV.MethodsEight artificially ventilated New Zealand rabbits were included in the experiments. EFL was induced during MV by application of negative expiratory pressure (−5, −8 and −10 hPa) and detected by the negative expiratory pressure (NEP) technique. Airway pressure (Paw) and flow (Vʹ) were digitally recorded and processed off-line for the evaluation of respiratory mechanics. The method is based on the computation and monitoring of instantaneous respiratory resistance Rrs(t). The resistive pressure (Paw,res(t)) is calculated by subtracting from Paw its elastic component and the end expiratory pressure (EEP), as assessed by linear regression. Then, Rrs(t) is computed as the instant ratio Paw,res(t)/Vʹ(t).ResultsTwo completely different patterns of expiratory Rrs(t) separate the cases with EFL from those without EFL. Small and random fluctuations are noticed when EFL is absent, whereas the onset of EFL is accompanied by an abrupt and continuous rise in Rrs(t), towards the end of expiration. Thus, EFL is not only detected but may also be quantified from the volume still to be expired at the time EFL occurs.ConclusionThe proposed technique is a simple, accurate and non-interventional tool for the EFL monitoring during MV.

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“…The method is well established during various modes of mechanical ventilation, permitting the calculation of EEP, which corresponds to the sum of any externally applied plus any intrinsically developed positive end-expiratory pressure (PEEP e + PEEP i ) [17-21]. The evaluation of X rs , Z rs and φ rs was based on the elastance and resistance estimated by MLRA.…”

Section: Discussionmentioning

confidence: 99%

Immediate post-operative effects of tracheotomy on respiratory function during mechanical ventilation

et al. 2004

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IntroductionTracheotomy is widely performed in the intensive care unit after long-term oral intubation. The present study investigates the immediate influence of tracheotomy on respiratory mechanics and blood gases during mechanical ventilation.MethodsTracheotomy was performed in 32 orally intubated patients for 10.5 ± 4.66 days (all results are means ± standard deviations). Airway pressure, flow and arterial blood gases were recorded immediately before tracheotomy and half an hour afterwards. Respiratory system elastance (Ers), resistance (Rrs) and end-expiratory pressure (EEP) were evaluated by multiple linear regression. Respiratory system reactance (Xrs), impedance (Zrs) and phase angle (φrs) were calculated from Ers and Rrs. Comparisons of the mechanical parameters, blood gases and pH were performed with the aid of the Wilcoxon signed-rank test (P = 0.05).ResultsErs increased (7 ± 11.3%, P = 0.001), whereas Rrs (-16 ± 18.4%, P = 0.0003), Xrs (-6 ± 11.6%, P = 0.006) and φ rs (-14.3 ± 16.8%, P = <0.001) decreased immediately after tracheotomy. EEP, Zrs, blood gases and pH did not change significantly.ConclusionLower Rrs but also higher Ers were noted immediately after tracheotomy. The net effect is a non-significant change in the overall Rrs (impedance) and the effectiveness of respiratory function. The extra dose of anaesthetics (beyond that used for sedation at the beginning of the procedure) or a higher FiO2 (fraction of inspired oxygen) during tracheotomy or aspiration could be related to the immediate elastance increase.

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Fourier analysis versus multiple linear regression to analyse pressure-flow data during artificial ventilation

Cited by 12 publications

References 12 publications

Leak measurements in spontaneously breathing premature newborns by using the flow-through technique

Leak measurements in spontaneously breathing premature newborns by using the flow-through technique

Non-interventional monitoring of expiratory flow limitation during experimental mechanical ventilation

Immediate post-operative effects of tracheotomy on respiratory function during mechanical ventilation

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