2010
DOI: 10.1155/2010/608749
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Fourier transform infrared and near-infrared spectroscopic methods for the detection of toxic Diethylene Glycol (DEG) contaminant in glycerin based cough syrup

Abstract: Abstract.Recently there have been reports of the contamination of cough syrups with Diethylene Glycol (DEG). The consumption of such cough syrups has devastating effects on the health. In this paper we report evidence that Fourier transform infrared (FT-IR) and near-infrared (NIR) spectroscopic techniques are viable, simple, cost effective, rapid and fool proof methods for the identification and quantification of DEG in glycerin based cough syrups. The FT-IR and NIR spectra of the glycerin based cough syrup an… Show more

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Cited by 51 publications
(25 citation statements)
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“…The sharp peak at 1043 cm À1 is related to the C-O stretching, while the C-O-H stretching is represented by the peak at 924 cm À1 . 73 The FTIR spectrum of the liquid garlic extract has a similar peak to the other results, which is a broad peak appearing at 3415 cm À1 . This peak represents the stretching vibration of O-H from the hydroxyl group, which indicates the presence of polyhydroxy compounds, including avonoids, non-avonoids, and saponins.…”
Section: Ftir Spectrasupporting
confidence: 79%
“…The sharp peak at 1043 cm À1 is related to the C-O stretching, while the C-O-H stretching is represented by the peak at 924 cm À1 . 73 The FTIR spectrum of the liquid garlic extract has a similar peak to the other results, which is a broad peak appearing at 3415 cm À1 . This peak represents the stretching vibration of O-H from the hydroxyl group, which indicates the presence of polyhydroxy compounds, including avonoids, non-avonoids, and saponins.…”
Section: Ftir Spectrasupporting
confidence: 79%
“…FTIR spectra of pure glycerol showed similar CO and COH stretching with chickpea flour‐based films. In FTIR spectra of glycerol, the peaks were observed at 1108 and 1030 representing CO stretching, and at 993 and 922 representing COH stretching …”
Section: Resultsmentioning
confidence: 99%
“…In addition, the absorptions at 1,020 to 1,050 cm −1 and 1,070 to 1,110 cm −1 indicate the C-O stretching vibrations in chitosan, which are associated with the C6-OH primary alcohol and the C3-OH secondary alcohol, respectively, and the bands at 1,160 and 996 cm −1 are assigned to the vibrations of the C-O-C saccharide bridge [ 36 ]. The modification of chitosan with the ethylene glycol (EG) moiety introduced chemical groups in the polymer chain (G-CHI) such as ether (C-O-C, 1,150 to 1050 cm −1 ), alcohol (−C-O, 1,260 to 1,000 cm −1 ), alkane (CH, 2,960 to 2,850 cm −1 and 1,450 to 1,300 cm −1 ), and hydroxyl (OH, 3,600 to 3,200 cm −1 ) [ 37 , 38 ], which mostly overlap the chitosan absorption bands. In addition to these bands, in the spectrum of the as-supplied glycol chitosan, the vibrations at 945 and 892 cm −1 , associated with –CH 2 rocking [ 37 ] and the –OC 2 H 4 backbone [ 38 ], respectively, were observed.…”
Section: Resultsmentioning
confidence: 99%
“…The modification of chitosan with the ethylene glycol (EG) moiety introduced chemical groups in the polymer chain (G-CHI) such as ether (C-O-C, 1,150 to 1050 cm −1 ), alcohol (−C-O, 1,260 to 1,000 cm −1 ), alkane (CH, 2,960 to 2,850 cm −1 and 1,450 to 1,300 cm −1 ), and hydroxyl (OH, 3,600 to 3,200 cm −1 ) [ 37 , 38 ], which mostly overlap the chitosan absorption bands. In addition to these bands, in the spectrum of the as-supplied glycol chitosan, the vibrations at 945 and 892 cm −1 , associated with –CH 2 rocking [ 37 ] and the –OC 2 H 4 backbone [ 38 ], respectively, were observed. Note that the primary amine band of the as-supplied glycol chitosan was shifted from 1,560 to 1,590 cm −1 compared with chitosan.…”
Section: Resultsmentioning
confidence: 99%