Fourier transform infrared spectroscopy for in-process inspection, counterfeit detection and quality control of anti-diabetic drugs

Farouk, Faten; Moussa, Bahia Abbas; Azzazy, Hassan M. E.

doi:10.1155/2011/975284

Cited by 16 publications

(10 citation statements)

References 17 publications

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“…The FTIR spectrum of pure repaglinide showed characteristic peaks at 3307. (-CH3 stretching) [27]. Symmetric stretching peaks of carboxylate salt groups were observed in the FTIR spectrum of sodium alginate.…”

Section: Fourier Transform Infrared (Ftir) Spectroscopymentioning

confidence: 91%

Dual crosslinked pectin–alginate network as sustained release hydrophilic matrix for repaglinide

Awasthi¹,

Kulkarni

Ramana

et al. 2017

International Journal of Biological Macromolecules

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Repaglinide, an oral antidiabetic agent, has a rapid onset of action and short half-life of approximately 1h. Developing a controlled and prolonged release delivery system is required to maintain its therapeutic plasma concentration and to eliminate its adverse effects particularly hypoglycemia. The present study aimed to develop controlled release repaglinide loaded beads using sodium alginate and pectin with dual cross-linking for effective control of drug release. The prepared beads were characterized for size, percentage drug entrapment efficiency, in vitro drug release and the morphological examination using scanning electron microscope. For the comparative study, the release profile of a marketed conventional tablet of repaglinide (Prandin tablets 2mg, Novo Nordisk) was determined by the same procedure as followed for beads. The particle size of beads was in the range of 698±2.34-769±1.43μm. The drug entrapment efficiency varied between 55.24±4.61 to 82.29±3.42%. The FTIR results suggest that there was no interaction between repaglinide and excipients. The XRD and DSC results suggest partial molecular dispersion and amorphization of the drug throughout the system. These results suggest that repaglinide did not dissolve completely in the polymer composition and seems not to be involved in the cross-linking reaction. The percent drug release was decreased with higher polymer concentrations. In conclusion, the developed beads could enhance drug entrapment efficiency, prolong the drug release and enhance bioavailability for better control of diabetes.

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Section: Fourier Transform Infrared (Ftir) Spectroscopymentioning

confidence: 91%

Dual crosslinked pectin–alginate network as sustained release hydrophilic matrix for repaglinide

Awasthi¹,

Kulkarni

Ramana

et al. 2017

International Journal of Biological Macromolecules

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“…This is a rapid technique which requires minimum or no pretreatment of the sample, provides accuracy comparable to other methods and also helps in the detection of counterfeiting and impurities. Through this technique, the sample can be scanned, on average, up to 64 times in any physical state and taking less than a minute with high resolution and precision [19]. Furthermore, it is a suitable technique for drugs with solubility problems, since they can be prepared in the pellet form [18].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, it is suitable for drugs with solubility problems, which can be prepared in powder form for obtaining pellets, and does not need the stage of extraction of the sample [18]. However, there are few studies in literature that use this region of the electromagnetic spectrum for this purpose [18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of the Quantitative Analysis of Ampicillin Sodium in Powder for Injection by Fourier-transform Infrared Spectroscopy (FT-IR)

Tótoli¹,

Salgado²

2013

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This paper describes the validation of an innovative analytical method for ampicillin sodium in powder for injection quantification, using Fourier-transform infrared (FT-IR) transmission spectroscopy. This technique does not use organic solvents, which is one great advantage over the most common analytical methods. This fact contributes to minimize the generation of organic solvent waste by the industry and thereby reduces the impact of its activities on the environment. The method involved absorbance measurements of the band corresponding to one of the carbonyl groups in the molecule, centered in the region between 1800 and 1700 cm-1. The method was validated according to ICH guidelines, showing to be linear (r = 0.9993), precise, accurate and robust, over a concentration range from 1.0 to 3.0 mg. The validated method is able to quantify ampicillin sodium in powder for injection preparation and can be used as an environmentally friendly alternative for the routine analysis in quality control.

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“…FTIR has excellent selectivity. [15] Attenuated Total Reflection Fourier-Transform infrared spectroscopy (ATR-FTIR) might be useful for the screening of counterfeit medicines since it is easy to use and little sample preparation is required. This study proposes a combination of ATR-FTIR and chemometrics to discriminate and classify counterfeit medicines.…”

Section: Infrared Spectroscopymentioning

confidence: 99%

Non-Destructive Analytical Techniques for Detection of Counterfeit Pharmaceutical Preparations

.¹,

.²,

.³

et al. 2018

JCPR

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Analytical methods development and validation play important roles in the discovery, development, and manufacture of pharmaceuticals. The development of the pharmaceuticals brought a revolution in human health. These pharmaceuticals would serve their intent only if they are free from impurities and are administered in an appropriate amount. Currently, counterfeit medicine is a significant issue for the pharmaceutical world, and it targets all types of therapeutic areas. These pharmaceuticals may develop impurities at various stages of their development, transportation and storage which makes the pharmaceutical risky to be administered thus they must be detected and quantitated on spot even. For this analytical instrumentation and methods play an important role. Many of the methods require varying degrees of irreversible sample preparation (removal from sealed container or blister pack, crushing into powder, dissolution with solvent, etc.) and therefore cannot be used in nondestructive mode. Now, direct methods to detect counterfeit products and to analyze the properties of the product itself are available. This can either be achieved using laboratory-based testing of purchased or seized samples, or can increasingly be done using portable, non-invasive techniques. This review highlights the role of the analytical instrumentation and the analytical methods in assessing the quality of the drugs.

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Fourier transform infrared spectroscopy for in-process inspection, counterfeit detection and quality control of anti-diabetic drugs

Cited by 16 publications

References 17 publications

Dual crosslinked pectin–alginate network as sustained release hydrophilic matrix for repaglinide

Dual crosslinked pectin–alginate network as sustained release hydrophilic matrix for repaglinide

Development and Validation of the Quantitative Analysis of Ampicillin Sodium in Powder for Injection by Fourier-transform Infrared Spectroscopy (FT-IR)

Non-Destructive Analytical Techniques for Detection of Counterfeit Pharmaceutical Preparations

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