Fournier's Disease: Adjunctive Hyperbaric Oxygen Therapy to Classic Therapy

Baykal, Kadir; Albayrak, Selami; Inal, H.; Elbüken, Emin; S, Kadir Dundar; Önol, Yavuz

doi:10.1111/j.1442-2042.1996.tb00505.x

Cited by 10 publications

(8 citation statements)

References 3 publications

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“…The illness is more frequently seen in men with poor hygiene, diabetes, paraplegia, cirrhosis and in alcoholics 2,6−8,10,11 . The findings from the present study support these results because 17 patients were diabetics, although one study reported that diabetes is not a factor in the outcome 13 .…”

Section: Discussionsupporting

confidence: 82%

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Fournier's gangrene: a retrospective clinical study on forty‐one patients

Ayan¹,

Sunamak²,

Paksoy³

et al. 2005

ANZ Journal of Surgery

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Section: Discussionsupporting

confidence: 82%

“…The pathology might be localized only to the scrotum or scattered to the penis, perineum, labia and abdominal wall 1−10 . FG may follow other colorectal and urinary system pathologies, infections and abscesses of the perineum, trauma to the penis or scrotum and any surgical interventions to the areas mentioned above.…”

Section: Introductionmentioning

confidence: 99%

Fournier's gangrene: a retrospective clinical study on forty‐one patients

Ayan¹,

Sunamak²,

Paksoy³

et al. 2005

ANZ Journal of Surgery

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“…Since 1883, when Jean Alfred Fournier first described what was then thought to be an idiopathic gangrene of the scrotum [ 4], the prognosis has been ominous. Mortality rates have been high despite the institution of a broad range of treatment protocols [ 5–9]. Over the past 3 years, the survival rate of our patients with Fournier’s gangrene has been high.…”

Section: Introductionmentioning

confidence: 99%

Fournier’s gangrene in a modern surgical setting: improved survival with aggressive management

1999

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Objective To examine the outcome of 23 consecutive patients with Fournier’s gangrene. Patients and methods Patients’ charts were reviewed retrospectively from all those treated for Fournier’s gangrene between July 1994 and July 1997 at the UCLA affiliated hospitals. Results Twenty‐three patients were identified (mean age 51.7 years, range 13–71). The aetiologies included perirectal abscess (43%), urethral stricture (30%), scrotal abscess (21%) and unknown (4%). Predisposing factors included diabetes mellitus (43%), steroids or chemotherapy (21%), alcohol abuse (43%), malignancy (26%) and radiation therapy (9%). All 23 patients initially received wide debridement and placement of a percutaneous suprapubic tube. At the time of the first surgery, total scrotectomy was required in all, colostomy in 17% and penectomy in 4%. An additional 35% required eventual colostomy and an additional 9% required a penectomy. Patients underwent repeat debridement a mean of 2.5 times; the overall survival was 96%. Conclusion Survival can be improved in patients with Fournier’s gangrene by combining aggressive surgical and medical management. The keys to successful outcome included a high index of suspicion, prompt fluid resuscitation, rapid initiation of broad‐spectrum antibiotics, a multidisciplinary approach, early surgical intervention with radical debridement, haemodynamic support in an intensive care setting, and frequent repeat operative debridement.

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“…It has long been recognised that the best treatment for synergistic gangrene is surgical excision, antibiotics having a secondary role. However, systemic corticosteroids [10] or adjunctive hyperbaric oxygen [1] could also play a therapeutic role. Since Fournier's gangrene is often, to "healthy" patients, wide incision and drainage of all involved areas and removal of all devitalized tissues should be performed as soon as the patient's medical condition allows.…”

Section: Discussionmentioning

confidence: 99%

Fournier's gangrene during induction treatment of acute promyelocytic leukemia, a case report

Lévy

Jaffarbey

Aouad

et al. 1998

Annals of Hematology

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Fournier's gangrene is described as a fulminant necrotizing fasciitis of the scrotum and penis. Few cases have been reported in the context of acute leukemia. We describe a case, complicating the induction treatment of an acute promyelocytic leukemia with all-trans-retinoic acid and chemotherapy. The evolution was favorable, following surgical excision and broad-spectrum antibiotic therapy. The respective roles of all-trans-retinoic acid and granulocytopenia are discussed. This devastating and life-threatening infection must be kept in mind for early clinical, bacteriological, and radiological diagnosis and surgical management.

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Fournier's Disease: Adjunctive Hyperbaric Oxygen Therapy to Classic Therapy

Cited by 10 publications

References 3 publications

Fournier's gangrene: a retrospective clinical study on forty‐one patients

Fournier's gangrene: a retrospective clinical study on forty‐one patients

Fournier’s gangrene in a modern surgical setting: improved survival with aggressive management

Fournier's gangrene during induction treatment of acute promyelocytic leukemia, a case report

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