Fournier Syndrome

Sackitey, Charlene; Tozer, Phil

doi:10.1007/978-3-030-76670-2_43

Cited by 1 publication

(1 citation statement)

References 55 publications

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“…In contrast to these data, our patient was of a young age, was neither hypertensive nor obese, and did not have a history of T2DM, but did have a history of smoking and alcohol abuse. According to data found in the literature, 25-50% of FG cases are associated with alcohol intake, and the rest with immunosuppression [33,34]. The pathophysiological process underlying the progression of the disease is based on hypoxia and low blood supply, which create a favorable environment for anaerobic microorganisms and also make it harder for antibiotics to reach their site of action.…”

Section: Discussionmentioning

confidence: 99%

Fournier’s Gangrene as an Adverse Event Following Treatment with Sodium Glucose Cotransporter 2 Inhibitors

Suciu,

Greluș,

Cozlac

et al. 2024

Medicina

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We present the case of a 51-year-old male with known congestive heart failure and acute myocarditis who presented to the emergency department (ED) with swollen testicles and urinary symptoms two weeks after the initiation of sodium glucose cotransporter 2 (SGLT2) inhibitor treatment. Abdominal and pelvic computed tomography (CT) scan was consistent with the diagnosis of Fournier’s gangrene (FG). Intravenous antibiotics were administered and surgical exploratory intervention and excision of necrotic tissue were performed, stopping the evolution of necrotizing fasciitis. FG, a reported adverse event, may rarely occur when SGLT2 inhibitors are administered in patients with diabetes. To our knowledge, there have been no reported cases of FG in Romania since SLGT2 inhibitors were approved. The distinguishing feature of this case is that the patient was not diabetic, which emphasizes that patients without diabetes who are treated for heart failure with SGLT2 inhibitors may also be at risk of developing genitourinary infections. The association of predisposing factors may have contributed to the development of FG in this case and even though the benefits of SGLT2 inhibitors outweigh the risks, serious adverse events need to be voluntarily reported in order to intervene promptly, verify the relationship, and minimize the risk of bias.

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Section: Discussionmentioning

confidence: 99%