Foveal microstructure and visual function in patients with lamellar macular hole, epiretinal membrane foveoschisis or macular pseudohole

Nakamura, Kentaro; Inoue, Tatsuya; Nagura, Koichi; Tanaka, Yoshinori; Arasaki, Rei; Asaoka, Ryo; Yanagi, Yasuo; Maruyama-Inoue, Maiko; Kadonosono, Kazuaki

doi:10.1038/s41433-021-01818-1

Cited by 4 publications

(6 citation statements)

References 14 publications

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“…However, no correlation of BCVA or CFT was found with flat or elevated type of ERM-Foveoschisis. Our findings are in line with earlier studies that indicated a correlation of lower BCVA with higher CFT in ERM-Foveoschisis [ 15 ]. However, there are other reports of 35 eyes with ERM-Foveoschisis [ 14 ] and 43 eyes with tractional LMH [ 9 ] that indicated a lower CFT in eyes with a lower BCVA.…”

Section: Discussionsupporting

confidence: 94%

“…In line with a recently published study by Nakamura et al that reported a CFT of 184.0 µm in ERM-Foveoschisis [ 15 ], we found a median CFT of 180.5 µm, higher than previous studies of LMH that showed a mean CFT of 72–132.69 µm [ 8 , 9 , 12 , 20 ].…”

Section: Discussionsupporting

confidence: 92%

“…Females showed dominance in our study group like in another study with a mixed cohort of tractional and degenerative LMH [ 12 ]. Some studies on ERM-Foveoschisis showed no difference in age and gender in eyes with ERM-Foveoschisis from those with LMH [ 13 – 15 ]. However, the last-mentioned cohorts were small and mixed with LMH or MPH.…”

Section: Discussionmentioning

confidence: 99%

“…Consistent with the study of Govetto et al, the eyes in our cohort showed an intact EZ in most cases. In a recent study, defects in the EZ were reported higher in eyes with LMH than in eyes with ERM-Foveoschisis resulting in a lower residual EZ and a lower BCVA [ 15 ]. Even though seen infrequently in our cohort, the EZ abnormality was associated with lower BVCA, if present.…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics of patients with epiretinal membrane-Foveoschisis

Hetzel

Neubauer

Gelişken

2022

Graefes Arch Clin Exp Ophthalmol

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Purpose The purpose of this study is to investigate the clinical and morphological characteristics of epiretinal membrane (ERM)-Foveoschisis. Methods Medical charts of 2088 patients diagnosed with idiopathic ERM were screened and eyes with ERM-Foveoschisis were included. All eyes underwent a complete ophthalmological examination including spectral domain optical coherence tomography (SD-OCT). OCT features and best corrected visual acuity (BCVA) were analysed. ERM-Foveoschisis was defined as open, closed, elevated or flat based on the OCT features. Ellipsoidal zone (EZ) abnormality, intraretinal cystoid spaces, central foveal thickness (CFT), posterior vitreous detachment (PVD) and lens status were assessed. Results One hundred-sixty-six patients (175 eyes) (72% female, mean age 70.46 years) were included. Incidence of ERM-Foveoschisis was 6.7%. Open type was seen in 86.8% and had a significantly better mean BCVA than closed type (p = 0.01). No statistically significant difference of mean BCVA was noted between the elevated and flat types. Mean BCVA was significantly lower in eyes with EZ abnormality (p = 0.03) and eyes with intraretinal cystoid spaces (p = 0.02). Patients with ‘closed’ ERM-Foveoschisis showed a significant higher median CFT than ‘open’ ERM-Foveoschisis (respectively, 364 µm and 176 µm, p < 0.001). A total of 81.9% eyes had PVD. Conclusion We differentiated four morphological types of ERM-Foveoschisis based on the OCT examination. Closed ERM-Foveoschisis presented with a higher CFT and lower BCVA than the open type. ERM-Foveoschisis with cystoid intraretinal spaces presented with a lower BCVA. The impact of the morphological types of the ERM-Foveoschisis on the clinical course and for therapy decision requires further long-term studies.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics of patients with epiretinal membrane-Foveoschisis

Hetzel

Neubauer

Gelişken

2022

Graefes Arch Clin Exp Ophthalmol

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“…The clear division of these three distinct clinical entities enables us to explore the characteristics of these diseases more accurately. Some studies have already compared the clinical characteristics and surgical outcomes among these three entities [8][9][10][11]. However, few studies have investigated the clinical characteristics of patients with ERM-FS as yet, especially the surgical prognosis [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Foveal Microstructure and Visual Outcomes after Pars Plana Vitrectomy in Patients with Different Types of Epiretinal Membrane Foveoschisis

Yang,

Wu,

et al. 2024

Ophthalmic Res

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Introduction: The aim of this study was to evaluate the clinical characteristics and surgical outcomes of the epiretinal membrane foveoschisis (ERM-FS) with different morphological types. Methods: This retrospective observational study reviewed 44 consecutive ERM-FS patients who underwent ERM surgery. According to the optical coherence tomography images, ERM-FS was classified into three groups: group A, FS crossed the fovea with the foveola elevated; group B, FS located at the foveal edges with a near-normal central foveal point thickness; and group C, FS with undermined foveal edges with a near-normal central foveal point thickness. Results: There were 10 eyes in group A, 20 eyes in group B, and 14 eyes in group C. Preoperatively, eyes in group A had the best best-corrected visual acuity (BCVA), the thickest central foveal point thickness, and the highest ellipsoid zone (EZ) intact rate among the three groups. After surgery, a resolution of foveoschisis was observed in 40.0%, 45.0%, and 50.0% of the eyes in group A, group B, and group C (p = 0.928), respectively. BCVA was significantly improved postoperatively. Although there was no significant difference in BCVA among the three groups at 1 month postoperatively, BCVA of group A was the best at 4 and 10 months. Correlation analysis indicated that the type of ERM-FS, baseline BCVA, central foveal point thickness, and postoperative EZ continuity (all p < 0.05) were important factors for the final BCVA. Conclusions: The damage to the retinal structure and visual function was milder in group A ERM-FS. Our study emphasized the necessity of OCT-based subtyping in patients with ERM-FS.

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Mixed Pathophysiologies of Lamellar Macular Holes and Related Diseases

Matoba,

Kanzaki,

Morita

et al. 2024

Retina

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Purpose: To investigate the characteristics of mixed pathophysiologies in lamellar macular holes (LMH) and related diseases using multimodal optical coherence tomography (OCT). Methods: Overall, 126 eyes diagnosed with LMH, epiretinal membrane foveoschisis (ERM-FS), or macular pseudohole (MPH) using the horizontal B-scan image according to the definition proposed by Hubschman et al. in 2020 were analyzed using multimodal OCT imaging including horizontal and vertical 5-line B-scan, radial scan, and macular three-dimensional volume scan images. If at least two diagnostic criteria for LMH, ERM-FS, or MPH were satisfied in these scans, the patient was diagnosed as having a "mixed type.” Retinal traction force was quantitatively evaluated by measuring the maximum depth of the retinal folds (MDRF) using en-face images. Results: Mixed types constituted 34.1% of the cases. The LMH-related mixed group demonstrated intermediate characteristics between the ERM-FS/MPH and true LMH groups in terms of retinal traction and LMH-specific features and had a significant positive correlation between the MDRF and mean M-CHARTS scores (P = 0.034). Conclusion: A thorough OCT analysis is necessary to accurately diagnose LMH and related diseases. A significant positive correlation was observed between the MDRF and the degree of metamorphopsia in the LMH-related mixed group.

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Foveal microstructure and visual function in patients with lamellar macular hole, epiretinal membrane foveoschisis or macular pseudohole

Cited by 4 publications

References 14 publications

Clinical characteristics of patients with epiretinal membrane-Foveoschisis

Clinical characteristics of patients with epiretinal membrane-Foveoschisis

Foveal Microstructure and Visual Outcomes after Pars Plana Vitrectomy in Patients with Different Types of Epiretinal Membrane Foveoschisis

Mixed Pathophysiologies of Lamellar Macular Holes and Related Diseases

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