Foveolar hyperplasia at the gastric cardia: prevalence and associations

Voutilainen, M; Juhola, Martti; Färkkilä, Martti; Sipponen, P

doi:10.1136/jcp.55.5.352

Cited by 18 publications

(11 citation statements)

References 26 publications

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“…Gastric foveola are either straight or slightly tortuous pits into which gastric glands empty [2]. In gastric foveolar cell hyperplasia (FCH), these pits become widened, tortuous and polypoid [6]. These hypertrophic polypoid lesions, if present at the pyloric inlet, are known to cause gastric outlet obstruction in adults [5], and are reported to be premalignant [3,5,7].…”

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confidence: 99%

Gastric Foveolar Cell Hyperplasia and its Role in Postoperative Vomiting in Patients with Infantile Hypertrophic Pyloric Stenosis

Tan¹,

Blythe²,

Kirby³

et al. 2009

Eur J Pediatr Surg

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mentioning

confidence: 99%

Gastric Foveolar Cell Hyperplasia and its Role in Postoperative Vomiting in Patients with Infantile Hypertrophic Pyloric Stenosis

Tan¹,

Blythe²,

Kirby³

et al. 2009

Eur J Pediatr Surg

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“…These findings are in agreement with both the series of Voutilainen 12 and Long. 20 They also provide additional evidence that the foveolar hyperplasia occurring at the gastroesophageal junction is unlikely to have a chemical reactive pathogenesis.…”

Section: Discussionmentioning

confidence: 94%

“…The second major series studied 31 individuals from Finland. 20 Recently, a series of 46 cases of hyperplastic polyps at the gastroesophageal junction was reported in abstract form. 12 Differences in the patient populations studied in these series (children vs. adults, inclusion or exclusion criteria, comparison with controls, correlation with biopsies from elsewhere in the upper gastrointestinal tract) and differences in histopathologic criteria, have yielded a varied spectrum of clinical and pathologic associations for these junctional polyps.…”

Section: Discussionmentioning

confidence: 99%

“…18 The first systematic histopathologic analyses of these lesions did not come up until the early 2000s. 1,20 These studies, conducted in dissimilar populations, reported a variety of clinicopathologic associations, did not always include a control group, and were not always in agreement with one another. During the last few years, we have collected data on such lesions, which we refer to as "cardiac polyps," from a large U.S. population.…”

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confidence: 99%

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Gastric Cardiac Polyps

Melton

Genta

2010

American Journal of Surgical Pathology

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As endoscopists have become more skilled in sampling the gastroesophageal junction, pathologists are being increasingly challenged to characterize previously unknown or neglected findings. One such example is the cardiac polyp. Originally described in the radiology literature as the sentinel fold, the first histologic descriptions of polyps at the gastroesophageal junction did not appear until less than a decade ago. Current clinicopathologic information is limited and somewhat conflicting. This study was designed to define the clinical, endoscopic, and histopathologic associations in patients with cardiac polyps. Using an electronic database, we extracted information on all patients who had a distal esophageal or esophagogastric junctional biopsy during a 24-month period. We then reviewed the slides of 330 adult patients diagnosed with a cardiac polyp and used semiquantitative or qualitative scales to score foveolar hyperplasia, inflammation, erosion or ulcers, epithelial type, and metaplasia. As controls we used 120,487 patients who had biopsies from the same anatomic sites during the same period, but were not diagnosed with a cardiac polyp. There were no significant differences among any clinical indications for esophagogastroduodenoscopy between study and control patients. Endoscopically, a polyp or nodule at the gastroesophageal junction was noted in 59.1% of the patients who had a histopathologic diagnosis of cardiac polyp. Histologically, Barrett mucosa, active esophagitis, and Helicobactor pylori gastritis were all significantly less common in patients with a cardiac polyp than in controls. Although relatively infrequent, synchronous hyperplastic polyps elsewhere in the stomach were significantly more common in patients than in controls. In conclusion, this large series suggests that cardiac polyps are rare but histologically distinct lesions. They are benign and are not uniquely associated with esophagitis, Barrett esophagus, gastroesophageal reflux disease, reactive gastropathy, or gastritis, with or without H. pylori.

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“…The presence of foveolar hyperplasia in the gastric mucosa occurs in patients with normal histological presentation of gastric mucosa. It may, however, be a consequence of chronic inflammation and its association with H. pylori [ 26 ]. This finding had significant value (P < 0.001) in both the antrum and fundic regions.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori Infection in Samples of Gastric Biopsies

et al. 2017

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BackgroundHelicobacter pylori (H. pylori) infection affects about 50% of the world population and its association with environmental factors and host properties is involved in gastric carcinogenesis. The study aimed to estimate the prevalence of H. pylori in samples of gastric mucosa biopsies, correlate the presence of the bacteria in the sample with the variables age, sex and origin, to identify the types of lesions found in patients with H. pylori, and to evaluate the association of the lesions with the region of the gastric mucosa.MethodsA cross-sectional, retrospective study was carried out in Aracaju, Sergipe, Brazil, from January 2013 to December 2015. A total of 45,206 gastric mucosal biopsies were obtained from patients submitted to upper gastrointestinal endoscopy. Of the reports evaluated, 12,909 met the inclusion criteria since they presented the patient’s demographic data as well as the histopathological characteristics of gastric mucosal regions and positivity for H. pylori. Data were analyzed by IBM SPSS Statistic 20 and subjected to descriptive analyses (categorical variables) and inferential (Pearson’s Qui-square and linear association tests) and multiple correspondence analyses. Significance level adopted 5%.ResultsOf the total of 12,909 (28.6%) reports evaluated, 67% (8,647) came from urban areas and 64.5% (8,320) were female. The mean age (standard deviation (SD)) was 43 years, ranging from 8 to 100 years, prevailing between 21 and 60 years. Among the types of gastric mucosa analyzed, 95.5% (12,322) were of the antral mucosa. The absence of glandular atrophy, the mild infection intensity for H. pylori, the absence of metaplasia, the presence of foveolar hyperplasia and lymphoid follicles were statistically significant (P < 0.001) in this region. In the fundic region, the evidence of fibrinoleucocytic crust and lymphoid follicles was significant (P < 0.001). There was no evidence of associated ulcerated lesions or significant relationship with intestinal metaplasia in the antral mucosa, whereas the fundic mucosa had a strong association with lymphoid follicles. The prevalence of active H. pylori infection in this study was 30.93%.ConclusionDetection rate of H. pylori and its association with acute and chronic inflammation should be taken into account. The antral region has shown higher incidence and the presence of H. pylori was strongly associated with foveolar hyperplasia and lymphoid follicles.

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Foveolar hyperplasia at the gastric cardia: prevalence and associations

Cited by 18 publications

References 26 publications

Gastric Foveolar Cell Hyperplasia and its Role in Postoperative Vomiting in Patients with Infantile Hypertrophic Pyloric Stenosis

Gastric Foveolar Cell Hyperplasia and its Role in Postoperative Vomiting in Patients with Infantile Hypertrophic Pyloric Stenosis

Gastric Cardiac Polyps

Prevalence of Helicobacter pylori Infection in Samples of Gastric Biopsies

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