Fowl Adenovirus: Pathogenesis and Control

Haiyilati, Areayi; Li, Xiaoqi; Zheng, Shijun

doi:10.26502/ijpaes.202122

Cited by 4 publications

(5 citation statements)

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“…One such innate immune component is avian ß-defensins (AvBDs), which play a pivotal role in viral infections. It has been reported that most AvBDs (AvBD 5, 7, 8, 9, and 13) were upregulated in specific FAdV-4-infected fowl tissues, and a positive correlation was observed between the FAdV-4 genome levels and upregulation of the aforementioned AvBDs, suggesting the important role of AvBDs in the immune response to FAdV-4 infection ( Haiyilati et al., 2021 ). In addition, the host immune system initiates an immune response by inducing the production of antiviral factors after recognizing viral pathogen-associated molecular patterns through pattern recognition receptors (PRRs).…”

Section: The Role Of Fadv-4 Infection In Host Immune Responsesmentioning

confidence: 96%

“…Lymphocyte numbers were also decreased in the bursa of Fabricius. These observations suggested that FAdV-4 escapes the adaptive immune response of host chickens ( Haiyilati et al., 2021 ). Infection of SPF chickens with FAdV-4 resulted in atrophy of the bursa of Fabricius, a decrease in lymphocyte count and a decrease in the number of B and T cells in lymphoid organs ( El-Shall et al., 2022 ).…”

Section: The Role Of Fadv-4 Infection In Host Immune Responsesmentioning

confidence: 99%

“…The PX protein is critical for apoptosis, and lymphocyte apoptosis causes immunosuppression. However, the detailed mechanism by which FAdV-4 induces apoptosis leading to immunosuppression still needs to be investigated ( Haiyilati et al., 2021 ). Species immunity and genetic background might also be factors involved in immune evasion by FAdV-4.…”

Section: The Role Of Fadv-4 Infection In Host Immune Responsesmentioning

confidence: 99%

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Biological features of fowl adenovirus serotype-4

Rashid,

Xie,

Wei

et al. 2024

Front. Cell. Infect. Microbiol.

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Fowl adenovirus serotype 4 (FAdV-4) is highly pathogenic to broilers aged 3 to 5 weeks and has caused considerable economic loss in the poultry industry worldwide. FAdV-4 is the causative agent of hydropericardium-hepatitis syndrome (HHS) or hydropericardium syndrome (HPS). The virus targets mainly the liver, and HPS symptoms are observed in infected chickens. This disease was first reported in Pakistan but has now spread worldwide, and over time, various deletions in the FAdV genome and mutations in its major structural proteins have been detected. This review provides detailed information about FAdV-4 genome organization, physiological features, epidemiology, coinfection with other viruses, and host immune suppression. Moreover, we investigated the role and functions of important structural proteins in FAdV-4 pathogenesis. Finally, the potential regulatory effects of FAdV-4 infection on ncRNAs are also discussed.

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Section: The Role Of Fadv-4 Infection In Host Immune Responsesmentioning

confidence: 96%

Section: The Role Of Fadv-4 Infection In Host Immune Responsesmentioning

confidence: 99%

Section: The Role Of Fadv-4 Infection In Host Immune Responsesmentioning

confidence: 99%

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Biological features of fowl adenovirus serotype-4

Rashid,

Xie,

Wei

et al. 2024

Front. Cell. Infect. Microbiol.

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“…Adenoviruses are distributed worldwide and infect a wide range of vertebrates including humans and animals [1]. According to the International Committee on Taxonomy of Viruses (ICTV), the family Adenoviridae includes six genera: Mastadenovirus, Aviadenovirus, Siadenovirus, Atadenovirus, Ichtadenovirus, and Testadenovirus [2].…”

Section: Introductionmentioning

confidence: 99%

Occurrence and phylogenetic analysis of fowl adenovirus E in broiler flocks from Gaza Strip Palestine

Thabet¹,

Alzuheir

Fayyad

et al. 2023

J Infect Dev Ctries

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Introduction: Inclusion-body hepatitis (IBH) and hydropericardium syndrome (HPS) are highly infectious diseases caused by fowl adenoviruses (FAdVs). IBH and HPS cause major economic losses in poultry production. IBH is caused by multiple FAdV serotypes such as FAdV-11, FAdV8a, and FAdV8b; while HPS is mainly caused by the FAdV-4 serotype. In 2018, we detected FAdVs in West Bank - Palestine for the first time. This study aims to monitor the emergence of new FAdVs in broiler farms in Gaza Strip-Palestine in 2022. Methodology: The clinical signs, necropsy, and histopathological findings associated with IBH in the suspected birds were recorded. Polymerase chain reaction (PCR) was performed using primers matching the virus-encoded L1 loop of the hexon gene. The sequences of the L1 loop were analyzed and a phylogenetic tree was constructed and compared with the related FAdV field isolates and reference strains from different regions of the world available in GenBank. Results: The infected broiler displayed FAdVs-induced clinical symptoms and pathological lesions with mortality rates ranging from 20-46%. The L1 loop sequences from the infected flocks were submitted to GenBank with accession numbers ON638995, ON872150, and ON872151. The identified L1 loop gene has high nucleotide homology (96.7-97.9%) to the highly pathogenic FAdV E serotype 8b strain FAdV_isolate_04-53357-122_Canada_2007 (GenBank: EF685489) and 94.5-94.6% to FAdV_10_Belgium_2010 isolate 11-15941 (GenBank: AF339924.1). Furthermore, the phylogenetic analysis indicated that they belong to FAdV-E serotype 8b. Conclusions: Our study reports the emergence of FAdV-E causing IBH disease in broiler chickens for the first time in Gaza in Palestine.

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“…PX, another structural protein of FAdV, is involved in attaching the linear double-stranded DNA genome to the capsid during replication [ 19 ] and induces apoptosis in FAdV-4-infected LMH cells, serving as a virulence factor for FAdV-4 infection [ 20 ]. In addition, other viral proteins were also involved in the pathogenesis of FAdV-4 infection [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Gga-miR-30c-5p Enhances Apoptosis in Fowl Adenovirus Serotype 4-Infected Leghorn Male Hepatocellular Cells and Facilitates Viral Replication through Myeloid Cell Leukemia-1

Haiyilati

Zhou

et al. 2022

Viruses

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Fowl adenovirus serotype 4 (FAdV-4) is the primary causative agent responsible for the hepatitis-hydropericardium syndrome (HHS) in chickens, leading to considerable economic losses to stakeholders. Although the pathogenesis of FAdV-4 infection has gained attention, the underlying molecular mechanism is still unknown. Here, we showed that the ectopic expression of gga-miR-30c-5p in leghorn male hepatocellular (LMH) cells enhanced apoptosis in FAdV-4-infected LMH cells by directly targeting the myeloid cell leukemia-1 (Mcl-1), facilitating viral replication. On the contrary, the inhibition of endogenous gga-miR-30c-5p markedly suppressed apoptosis and viral replication in LMH cells. Importantly, the overexpression of Mcl-1 inhibited gga-miR-30c-5p or FAdV-4-induced apoptosis in LMH cells, reducing FAdV-4 replication, while the knockdown of Mcl-1 by RNAi enhanced apoptosis in LMH cells. Furthermore, transfection of LMH cells with gga-miR-30c-5p mimics enhanced FAdV-4-induced apoptosis associated with increased cytochrome c release and caspase-3 activation. Thus, gga-miR-30c-5p enhances FAdV-4-induced apoptosis by directly targeting Mcl-1, a cellular anti-apoptotic protein, facilitating FAdV-4 replication in host cells. These findings could help to unravel the mechanism of how a host responds against FAdV-4 infection at an RNA level.

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Fowl Adenovirus: Pathogenesis and Control

Cited by 4 publications

References 0 publications

Biological features of fowl adenovirus serotype-4

Biological features of fowl adenovirus serotype-4

Occurrence and phylogenetic analysis of fowl adenovirus E in broiler flocks from Gaza Strip Palestine

Gga-miR-30c-5p Enhances Apoptosis in Fowl Adenovirus Serotype 4-Infected Leghorn Male Hepatocellular Cells and Facilitates Viral Replication through Myeloid Cell Leukemia-1

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