FOXG1 is overexpressed in hepatoblastoma

Adesina, Adekunle M.; Nguyen, Yummy; Guanaratne, Preethi; Pulliam, Joseph F.; López‐Terrada, Dolores; Margolin, Judy; Finegold, Milton J.

doi:10.1016/j.humpath.2006.09.003

Cited by 44 publications

(28 citation statements)

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“…As earlier studies have shown that FOXG1 is able to block the transcription of p21 WAF1/CIP1 by counteracting TGF-b-induced signalling pathway and hence promoting cell proliferation (Seoane et al, 2004;Adesina et al, 2007a), it would be interesting to examine the gene expression of p21 WAF1/CIP1 in normal ovaries and ovarian cancer tissues. Using Q-PCR analysis, we found that p21 WAF1/CIP1 showed higher expression levels in normal ovarian tissues when compared with ovarian tumour (Po0.0001) ( Figure 1C).…”

Section: Overexpression Of Foxg1 In Ovarian Cancermentioning

confidence: 99%

“…To examine whether the overexpressed FOXG1 exerts inhibitory role on TGF-b-induced p21 WAF1/CIP1 expression similar to earlier reports (Seoane et al, 2004;Adesina et al, 2007a), several ovarian cancer cell models were used. Genetic and/or epigenetic lesions usually deregulate TGF-b-mediated cell growth inhibitory effects in various human cancers, including ovarian cancer (Sakaguchi et al, 2005).…”

Section: The Effect Of Tgf-b On Ovarian Cancer Cellsmentioning

confidence: 99%

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Overexpression of FOXG1 contributes to TGF-β resistance through inhibition of p21WAF1/CIP1 expression in ovarian cancer

Chan

Liu

et al. 2009

Br J Cancer

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BACKGROUND: Loss of growth inhibitory response to transforming growth factor-b (TGF-b) is a common feature of epithelial cancers. Recent studies have reported that genetic lesions and overexpression of oncoproteins in TGF-b/Smads signalling cascade contribute to the TGF-b resistance. Here, we showed that the overexpressed FOXG1 was involved in attenuating the anti-proliferative control of TGF-b/Smads signalling in ovarian cancer. METHODS: FOXG1 and p21 WAF1/CIP1 expressions were evaluated by real-time quantitative reverse-transcription polymerase chain reaction (RT -PCR), western blot and immunohistochemical analyses. The effect of FOXG1 on p21 WAF1/CIP1 transcriptional activity was examined by luciferase reporter assays. Cell lines stably expressing or short hairpin RNA interference-mediated knockdown FOXG1 were established for studying the gain-or-loss functional effects of FOXG1. XTT cell proliferation assay was used to measure cell growth of ovarian cancer cells. RESULTS: Quantitative RT -PCR and western blot analyses showed that FOXG1 was upregulated and inversely associated with the expression levels of p21 WAF1/CIP1 in ovarian cancer. The overexpression of FOXG1 was significantly correlated with high-grade ovarian cancer (P ¼ 0.025). Immunohistochemical analysis on ovarian cancer tissue array was further evidenced that FOXG1 was highly expressed and significantly correlated with high-grade ovarian cancer (P ¼ 0.048). Functionally, enforced expression of FOXG1 selectively blocked the TGF-b-induced p21 WAF1/CIP1 expressions and increased cell proliferation in ovarian cancer cells. Conversely, FOXG1 knockdown resulted in a 20 -26% decrease in cell proliferation together with 16 -33% increase in p21 WAF1/CIP1 expression. Notably, FOXG1 was able to inhibit the p21 WAF1/CIP1 promoter activity in a p53-independent manner by transient reporter assays.

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Section: Overexpression Of Foxg1 In Ovarian Cancermentioning

confidence: 99%

Section: The Effect Of Tgf-b On Ovarian Cancer Cellsmentioning

confidence: 99%

Overexpression of FOXG1 contributes to TGF-β resistance through inhibition of p21WAF1/CIP1 expression in ovarian cancer

Chan

Liu

et al. 2009

Br J Cancer

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“…As células deste componente mostram citoplasma escasso, com pouco glicogênio e núcleos irregulares com cromatina densa, formando arranjos acinares, papilares ou até mesmo pseudo-rosetas. A atividade mitótica é bem mais proeminente (Bosman et al, 2010;Finegold et al, 2007).…”

Section: 5) Classificação Histopatológicaunclassified

“…As trabéculas são constituídas por células do componente epitelial, fetal e células maiores que se assemelham a hepatócitos ou células do hepatocarcinoma (Bosman et al, 2010;Finegold et al, 2007). O subtipo indiferenciado de pequenas células também representa cerca de 2-3% dos hepatoblastomas epiteliais e são constituídos por uma população de células pequenas, redondas e azuis, indiferenciadas.…”

Section: 5) Classificação Histopatológicaunclassified

“…O subtipo indiferenciado de pequenas células também representa cerca de 2-3% dos hepatoblastomas epiteliais e são constituídos por uma população de células pequenas, redondas e azuis, indiferenciadas. As células se arranjam em padrão sólido, e a neoplasia exibe áreas de necrose e contagem mitótica elevada (Bosman et al, 2010;Finegold et al, 2007). (Finegold et al, 2007).…”

Section: 5) Classificação Histopatológicaunclassified

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Estudo da expressão das proteínas TFE3 e receptor de insulina nos hepatoblastomas a partir dos achados de expressão gênica

Filippi¹

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RENÉE ZON FILIPPIEstudo da expressão das proteínas TFE3 "Choose a job you love, and you will never have to work a day in your life." Confucius DedicatóriaAo meu marido, por todo amor, paciência e dedicação, principalmente durante o tempo que estivemos longe um do outro (tempos de silver line). Te amo.Ao meu filho, Pedro Jun, que significa tudo para mim.Para minha mãe, Odilene , que sempre acreditou em mim.. E para o meu pai, Heitor, que mesmo em pouco tempo que tivemos juntos, me ensinou muito. AgradecimentosÁ minha orientadora, amiga e a quem admiro muito Dra Maria Claudia Zerbini, por toda a imprescindível ajuda na concepção e execução deste projeto, além de todo a paciência e o fundamental apoio psicológico.Á minha querida irmã, Ana Claudia, meu cunhado Márcio Terra Passos e minhas sobrinhas Jéssica e Bruna, responsáveis por vários momentos felizes e pelo incentivo durante o decorrer desta tese.Aos meus sogros Sunao e Tereza Kishi, por toda a ajuda, carinho e apoio.Á minha amiga e sócia na Pernóstika, Denise da Cunha Pasqualin, por seus conselhos, amizade, companheirismo e constante encorajamento. Muito obrigada! Ao meu colega de trabalho e amigo Carlos Saito, por toda a ajuda em tudo.Aos meus companheiros de trabalho no IOT, pessoas com quem tenho o privilégio de trabalhar e de quem gosto demais.Aos meus amigos e companheiros de trabalho da patologia do HIAE. É muito bom atrabalhar com vocês e obrigada pelo apoio constante.Aos grandes patologistas que conheço e com quem tive o prazer de conviver e que muito ajudaram na minha formação: Dr.

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Current issues and controversies in the classification of pediatric hepatocellular tumors

López‐Terrada

Zimmermann

2012

Pediatric Blood & Cancer

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Systematic histopathologic examination of hepatoblastoma specimens from patients enrolled in therapeutic protocols has allowed the identification of clinically relevant histologic subtypes that are being incorporated into risk stratification systems. Genetic and molecular studies have documented recurrent chromosomal abnormalities and aberrant activation of developmental, and oncogenic signaling pathways in hepatoblastoma. Molecular profiling has also identified molecular subclasses and gene signatures that could be used to stratify hepatoblastoma patients. Future international collaboration is needed to develop consensus pathology classifications, and to progressively incorporate genetic and molecular biomarkers into therapeutic pediatric liver tumors protocols.

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FOXG1 is overexpressed in hepatoblastoma

Cited by 44 publications

References 44 publications

Overexpression of FOXG1 contributes to TGF-β resistance through inhibition of p21WAF1/CIP1 expression in ovarian cancer

Overexpression of FOXG1 contributes to TGF-β resistance through inhibition of p21WAF1/CIP1 expression in ovarian cancer

Estudo da expressão das proteínas TFE3 e receptor de insulina nos hepatoblastomas a partir dos achados de expressão gênica

Current issues and controversies in the classification of pediatric hepatocellular tumors

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