FOXJ1 promotes bladder cancer cell growth and regulates Warburg effect

Xian, Shaozhong; Shang, Donghao; Kong, Guangqi; Tian, Ye

doi:10.1016/j.bbrc.2017.11.063

Cited by 24 publications

(19 citation statements)

References 20 publications

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“…19 Previous studies have proven that FOXJ1 promotes bladder cancer cells growth through regulating glycolysis, as evidenced by the increased glucose uptake, lactate production, and extracellular acidification rate, along with decreased ATP generation and oxygen consumption rate. 15 In the current work, we found that FOXJ1-siRNA inhibited glucose consumption and lactate production, indicating that FOXJ1 knockdown suppressed glycolysis in LSCC cells. Besides, FOXJ1 knockdown reduced cell proliferation, migration, and invasion.…”

Section: Discussionsupporting

confidence: 48%

Knockdown of FOXJ1 inhibits the proliferation, migration, invasion, and glycolysis in laryngeal squamous cell carcinoma cells

Liu

Zhang

Shao

et al. 2019

J of Cellular Biochemistry

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Forkhead box (FOX) proteins are a large family of transcription factors that are involved in multiple biological processes. FOXJ1, a member of the FOX family, has been found to participate in tumorigenesis. However, the role of FOXJ1 in laryngeal squamous cell carcinoma (LSCC) is still unclear. The aim of the present study was to explore the potential roles of FOXJ1 in LSCC. Our results showed that FOXJ1 was overexpressed in LSCC tissues and cell lines. Then the small interfering RNA targeting FOXJ1 (FOXJ1‐siRNA) or control siRNA was transfected into TU‐177 and AMC‐HN‐8 cells to knockdown FOXJ1. Cell Counting Kit‐8 assay showed that knockdown of FOXJ1 inhibited the proliferation of LSCC cells. Transwell assay revealed that FOXJ1‐siRNA‐transfected cells showed significant reduction in cell migration and invasion compared to the cells transfected with control siRNA. FOXJ1 knockdown suppressed glycolysis in LSCC cells, which was illustrated by the reduced glucose consumption and lactate production. In addition, FOXJ1 knockdown inhibited the activation of the Wnt/β‐catenin pathway, and the LiCl treatment mitigated the inhibitory effects of FOXJ1‐siRNA on cell proliferation, migration, invasion, and glycolysis. These findings indicated that FOXJ1‐siRNA executed its functions via suppressing the activation of the Wnt/β‐catenin pathway.

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Section: Discussionsupporting

confidence: 48%

Knockdown of FOXJ1 inhibits the proliferation, migration, invasion, and glycolysis in laryngeal squamous cell carcinoma cells

Liu

Zhang

Shao

et al. 2019

J of Cellular Biochemistry

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“…Similarly, the up-regulation of FOXJ1 is linked to higher histological grade and poor prognosis of liver cancer via cell proliferation and cell-cycle progression of the tumor cells [ 110 ]. FOXJ1 also induces proliferation and colony formation of bladder cancer cells, due in part to aberrant metabolism of the cancer cells [ 111 ]. However, FOXJ1 appears to play dual roles since lower expression of FOXJ1 is associated with worse prognosis of patients with gastric carcinoma [ 112 ].…”

Section: An Overview Of Recent Insights On Foxs In Cancermentioning

confidence: 99%

The Dominant Role of Forkhead Box Proteins in Cancer

Bach

Long

Luu

et al. 2018

IJMS

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Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly implicated in cancer, with various critical roles in biological processes. Herein, we provide an overview of several key members of the FOXA, FOXC, FOXM1, FOXO and FOXP subfamilies. Important pathophysiological processes of FOX transcription factors at multiple levels in a context-dependent manner are discussed. We also specifically summarize some major aspects of FOX transcription factors in association with cancer research such as drug resistance, tumor growth, genomic alterations or drivers of initiation. Finally, we suggest that targeting FOX proteins may be a potential therapeutic strategy to combat cancer.

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“…For example, FOXJ1 can promote aerobic glycolysis and proliferation of bladder cancer cells. FOXJ1 upregulation is associated with a poor clinical prognosis of the patients [11]. MiR-4999-5p can regulate the glycolysis of the colorectal cancer cells and promote the clone formation, proliferation and invasion of the colorectal cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Identifying novel cell glycolysis related gene signature predictive of overall survival in bladder urothelial carcinoma

Zhao¹,

Li²,

Li³

et al. 2020

Preprint

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Background: Bladder urothelial carcinoma (BLCA) is the most common pathological type of bladder cancer and featured by a high risk for relapse and metastasis. Although many biomarkers have been developed by data mining and experimental studies to predict the prognosis of BLCA, a single-gene biomarker usually has poor specificity and sensitivity, leading to unsatisfactory prediction. Therefore, novel gene signatures are needed to more accurately predict the prognosis of BLCA.Methods: Data mining was performed for expression profile analysis of 433 mRNA expression data from the TCGA BLCA patients (n=412). Gene Set Enrichment Analysis (GSEA) was used to interpret the glycolysis-related gene sets. Gene signature related to the prognosis of BLCA was identified by univariate and multivariate Cox regression. A risk score was computed based on three genes by linear regression model and its relation with overall survival was investigated by Kaplan-Meier analysis.Results: Three genes (CHPF, AK3, NUP188) were found to be significantly correlated to the overall survival of BLCA patients. Based on the signature composed of these three genes, 412 BLCA patients were divided into high-risk and low-risk groups. The survival time of the high-risk group was significantly shorter than that of the low-risk group, indicating a worse prognosis.Conclusion: A signature composed of three glycolysis-related genes was developed as biomarkers to predict the prognosis of BLCA and to provide a meaningful reference for the clinical treatment of BLCA.

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FOXJ1 promotes bladder cancer cell growth and regulates Warburg effect

Cited by 24 publications

References 20 publications

Knockdown of FOXJ1 inhibits the proliferation, migration, invasion, and glycolysis in laryngeal squamous cell carcinoma cells

Knockdown of FOXJ1 inhibits the proliferation, migration, invasion, and glycolysis in laryngeal squamous cell carcinoma cells

The Dominant Role of Forkhead Box Proteins in Cancer

Identifying novel cell glycolysis related gene signature predictive of overall survival in bladder urothelial carcinoma

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