FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced by <i>Pseudomonas aeruginosa</i>

Liu, Yuru; Sadikot, Ruxana T.; Adami, Guy R.; Kalinichenko, Vladimir V.; Pendyala, Srikanth; Natarajan, Viswanathan; Zhao, You Yang; Malik, Asrar B.

doi:10.1084/jem.20102041

Cited by 87 publications

(119 citation statements)

References 47 publications

Supporting

Mentioning

112

Contrasting

Order By: Relevance

“…Expression of Sca-1, a marker of BASCs [7] and a subpopulation of Type 2 cells [22], was significantly higher in airway EpCAM pos integrin a6 high cells consistent with previous observations that this marker is shared by several progenitor cell populations [5]. Expression of KDR mRNA in the airway EpCAM pos integrin a6 high epithelial population was increased as well, supporting the notion that KDR marks airway epithelial progenitors [11].…”

Section: Microdissection Of Conducting Airways and Lung Parenchyme Ofsupporting

confidence: 90%

Behavioral Heterogeneity of Adult Mouse Lung Epithelial Progenitor Cells

Chernaya

Shinin²,

Liu³

et al. 2014

Stem Cells and Development

Self Cite

View full text Add to dashboard Cite

The existence and identity of multipotent stem cells in the adult lung is currently highly debated. At present, it remains unclear whether candidate stem/progenitor cells are located in the airways, alveoli, or throughout the epithelial lining of the lung. Here, we introduce a method of airway microdissection, which enabled us to study the progenitor behavior of pulmonary epithelial cells in region-specific contexts. The progenitor characteristics of epithelial cells isolated from the trachea, proximal and distal airways, and lung parenchyme were evaluated in vitro and in vivo. We identified a population of airway-derived basal-like epithelial cells with the potential to self-renew and differentiate into airway and alveolar lineages in culture and in vivo after subcutaneous transplantation. The multipotent candidate progenitors originated from a minor fraction of the airway epithelial cell population characterized by high expression of a6 integrin. Results of the current study provide new insights into the regenerative potential of region-specific integrin a6-positive pulmonary epithelial cells.

show abstract

Section: Microdissection Of Conducting Airways and Lung Parenchyme Ofsupporting

confidence: 90%

Behavioral Heterogeneity of Adult Mouse Lung Epithelial Progenitor Cells

Chernaya

Shinin²,

Liu³

et al. 2014

Stem Cells and Development

Self Cite

View full text Add to dashboard Cite

show abstract

“…As would be expected, Sio transcription (8). To determine whether FOXM1 is sufficient to drive expression of cell cycle-regulated genes in CCL210 cells, we employed both CMV T7 promoter-driven and adenoviral-driven FOXM1 overexpression (16,17) (Supplemental Figure 4, A-C). Indeed, forced overexpression of FOXM1 resulted in transcriptional activation of cell cycle-regulated genes ( Figure 2E and Supplemental Figure 4D) and was potentiated by FGF2 stimulation (Supplemental Figure 4D).…”

Section: Fibrotic Fibroblasts Exhibit Increased Foxm1 Expressionmentioning

confidence: 99%

FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis

Penke

Speth

Dommeti

et al. 2018

Journal of Clinical Investigation

100

View full text Add to dashboard Cite

“…In many cases, these studies are still at the in vitro stages, such as the use of vimentin to improve wound repair [30], or just suggest a possible benefi cial role (e.g., connexins [31], adrenomedullin [32] or a possible modulation of the transcription factors, FoxM1 and Runx3 [33,34]) and need further research to prove their viability in vivo. Improvement of plasma membrane repair is a possible direct treatment.…”

Section: Therapeutic Strategies Aimed At Lung Repairmentioning

confidence: 99%