2024
DOI: 10.1186/s40779-024-00523-w
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FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury

Mi Zhou,
Yang-Wu-Yue Liu,
Yu-Hang He
et al.

Abstract: Background Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury (TBI). However, the heterogeneity, multifunctionality, and time-dependent modulation of brain damage and outcome mediated by neutrophils after TBI remain poorly understood. Methods Using the combined single-cell transcriptomics, metabolomics, and proteomics analysis from TBI patients and the TBI mouse model, we … Show more

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