FOXO4 expression associates with glioblastoma development and FOXO4 expression inhibits cell malignant phenotypes in vitro and in vivo

Qi, Min; Sun, Lean; Jiang, Xiaochun; Han, Yanling; Wang, Lin; Niu, Wenhao; Fei, Maoxing; Zhaba, Wang-Dui; Zheng, Lan-rong; Zhou, Meng-Liang

doi:10.1016/j.lfs.2020.117436

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…As can be seen in Figure 3 A, FOXO4 is decreased in several types of nervous system tumors, including GBM. It is reported that FOXO4 possesses an anticancer glioma activity [ 53 ]. Therefore, molecular mechanism studies are warranted to clarify and assess whether elevation of FOXM1 and simultaneously decrease of FOXO4 could act as a diagnostic marker for GBM.…”

Section: Discussionmentioning

confidence: 99%

An Integrated Study on the Differential Expression of the FOX Gene Family in Cancer and Their Response to Chemotherapy Drugs

Yin

Fan

Zhang

et al. 2022

Genes

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The Forkhead-box (FOX) transcription factors, as one of the largest gene families in humans, play key roles in cancer. Although studies have suggested that several FOX transcription factors have a significant impact on cancer, the functions of most of the FOX genes in cancer remain elusive. In the study, the expression of 43 FOX genes in 63 kinds of cancer diseases (including many subtypes of same cancer) and in response to 60 chemical substances was obtained from the Gene Expression Atlas database of the European Bioinformatics Institute. Based on the high degree of overlap in FOXO family members differentially expressed in various cancers and their particular responses to chemotherapeutic drugs, our data disclosed the FOX genes that played an important role in the development and progression of cancer. More importantly, we predicted the role of one or several combinatorial FOX genes in the diagnosis and prognostic assessment of a specific cancer and evaluated the potential of a certain anticancer drug therapy for this type of cancer by integrating patterns of FOX genes expression with anticancer drugs sensitivity.

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Section: Discussionmentioning

confidence: 99%

An Integrated Study on the Differential Expression of the FOX Gene Family in Cancer and Their Response to Chemotherapy Drugs

Yin

Fan

Zhang

et al. 2022

Genes

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“…Cholangiocarcinoma cell growth in vitro is repressed by FOXO4 via induction of G0/G1 arrest (36). FOXO4 also limits glioblastoma development by inhibiting the malignant phenotype of cells (25). In addition, FOXO4 has been shown to inhibit cervical cancer, gastric cancer, liver and nasopharyngeal cancer cell growth and tumor progression (37)(38)(39)(40).…”

Section: Discussionmentioning

confidence: 99%

“…(22)(23)(24). In glioblastomas, FOXO4 inhibits the malignant phenotype of cells in vitro and in vivo (25). Importantly, overexpression of FOXO4 promotes apoptosis of ccRCC cells by repressing Bim expression (26).…”

Section: Introductionmentioning

confidence: 99%

A Novel ZNF304/miR-183-5p/FOXO4 Pathway Regulates Cell Proliferation in Clear Cell Renal Carcinoma

et al. 2021

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Zinc-finger protein 304 (ZNF304) plays a critical role in silencing genes through transcription, regulating cell survival, proliferation, apoptosis, and differentiation during development. However, the roles of transcription factor ZNF304 and its clinical significance in clear cell renal carcinoma (ccRCC) remain unclear. In this study, we found that the expression of ZNF304 was downregulated in ccRCC tissues. Lower levels of ZNF304 were correlated with poor survival. Downregulation of ZNF304 promoted ccRCC cell growth in vitro, whereas overexpression of ZNF304 inhibited growth. Our results indicated that miR-183-5p/FOXO4 mediated ZNF304 regulation of cell growth. Interestingly, we revealed that ZNF304 promoted FOXO4 expression in ccRCC cells. Mechanistically, ZNF304 binds to miR-183 promoter and inhibits miR-183-5p transcription. Furthermore, the expression of miR-183-5p wes increased in ccRCC tissues, and the upregulation of miR-183-5p was related to the poor prognosis of ccRCC patients. miR-183-5p upregulation repressed the expression of FOXO4 and promoted ccRCC progression. These results demonstrated that ZNF304/miR-183-5p/FOXO4 axis played essential role in promoting ccRCC progression, which suggests that disruption of this axis may be a potential therapeutic target in ccRCC.

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“…According to Liu et al (2020), this family member is mostly involved in regulating genes which are responsible for metabolism, cell cycle, apoptosis and cellular homeostasis through transcriptional activity. Clinically, FOXO4 has been considered to be a novel tumor suppressor in many human cancers, including leukemia, neuroblastoma, cervical, colorectal, pancreatic and lung cancers (53)(54)(55).…”

Section: Endoplasmic Reticulum (Er) Stress-induced Cell Deathmentioning

confidence: 99%

Transcriptomic study of the cell death-related pathways of cervical cancer HeLa cells in response to Clinacanthus nutans treatment

Adum

Haron

Toha

et al. 2022

Preprint

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Background Recent years have witnessed major development of novel therapeutic agents like chemotherapy, targeted therapy and immune checkpoint inhibitors for cervical cancer. However, cervical cancer remains prevalent, leading to a large number of deaths worldwide. A better understanding of the cervical cancer biology and signaling pathways might lead to the development of targeted therapies in reducing the incidence and mortality rate. Methods In this study, the RNA-Seq reads of HeLa cells treated with C. nutans were compared to the untreated sample. The reads of these two sample groups were firstly aligned to the human reference genome. The results in BAM files format that were generated were then sorted before being assembled. The output of assembly which was in coverage table form was ready for downstream statistical analyses for differential expression. Differentially expressed genes were obtained and the cell-death related pathway were identified by canonical pathway, QIAGEN Ingenuity Pathway Analysis (IPA). The verification of significant genes was carried out using qRT-PCR by including GAPDH as a housekeeping gene Results With this, we identified a total of 668 upregulated and 479 downregulated analysis-ready genes across observations upon cut-off setting log2FoldChange at 0.5 and P-value 0.05. A total of 28 cell-death related canonical pathways and 4 activation of cell-death related functions were identified. Upon analyses, we identified four significant genes (Casp9, KAI1, REL and FOXO4) that hold important role in promoting cell death. These findings were also verified against the quantification using qRT-PCR by including GAPDH as a housekeeping gene. Conclusions This study provides an insight on the potential role of DCM fraction of C. nutans in activating Casp9, KAI1, REL and FOXO4 genes in mediating apoptosis in cervical cancer cells.

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FOXO4 expression associates with glioblastoma development and FOXO4 expression inhibits cell malignant phenotypes in vitro and in vivo

Cited by 9 publications

References 28 publications

An Integrated Study on the Differential Expression of the FOX Gene Family in Cancer and Their Response to Chemotherapy Drugs

An Integrated Study on the Differential Expression of the FOX Gene Family in Cancer and Their Response to Chemotherapy Drugs

A Novel ZNF304/miR-183-5p/FOXO4 Pathway Regulates Cell Proliferation in Clear Cell Renal Carcinoma

Transcriptomic study of the cell death-related pathways of cervical cancer HeLa cells in response to Clinacanthus nutans treatment

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