Foxp3&lt;sup&gt;+&lt;/sup&gt; Regulatory T Cells Are Increased in the Early Stages of Halo Nevi: Clinicopathological Features of 30 Halo Nevi

Park, H.S.; Jin, Shu‐Guang; Choi, Y.-D.; Shin, Myung-Geun; Lee, S.E.; Yun, Sook Jung

doi:10.1159/000342757

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…This finding is similar to another study on Asians. [ 15 ] This discrepancy between Caucasians and Asians is probably due to the fact that discoloration is more easily visible in Asians, who have darker skin than Caucasians. Especially, when the lesions are located on the areas that are easily perceived, the patients are more likely to seek medical treatment.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Development of Vitiligo in Patients with Halo Nevus

Zhou

Chen

et al. 2017

Chinese Medical Journal

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Background:Halo nevus (HN) has been shown to be associated with vitiligo, but no standard signs are currently available to identify HN patients at risk of vitiligo, and the relevant data obtained in previous studies are somewhat conflicting. This study aimed to identify factors affecting the presence of vitiligo in HN patients.Methods:We performed a retrospective study on consecutive patients with HN at the First Affiliated Hospital of Sun Yat-sen University between January 2011 and December 2016. Detailed demographic and clinical data were collected to identify the factors associated with the presence of vitiligo in this cohort of patients using uni- and multi-variate logistic regression analyses.Results:A total of 212 HN patients were included, 101 of whom had vitiligo-associated HN (HNV). Univariate analysis indicated that a personal history of thyroid diseases was positively associated with HNV (odds ratio [OR] = 10.761, P = 0.025), while the onset age of HN was negatively associated with HNV (OR = 0.537, P = 0.026). Multivariate analysis demonstrated that the Koebner phenomenon (KP; OR = 10.632, P < 0.0001), multiple HN (OR = 3.918, P < 0.0001), and a familial history of vitiligo (OR = 3.222, P = 0.014) were independent factors associated with HNV.Conclusions:HN without vitiligo has clinical features distinct from HN associated with vitiligo. HN patients with KP, multiple lesions, or familial history of vitiligo are more likely to develop vitiligo and therefore should be monitored for clinical signs of such accompanied conditions.

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Section: Discussionmentioning

confidence: 99%

Factors Associated with Development of Vitiligo in Patients with Halo Nevus

Zhou

Chen

et al. 2017

Chinese Medical Journal

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“…The inflammatory infiltrate in early regression stages of melanoma may look similar to the one in halo nevi. FOXP3 regulatory T cells are highly expressed in early stages of halo nevi [ 31 ], while in regression areas of melanoma, a small number of regulatory T cells was described [ 31 , 32 ]. The inflammatory cell infiltrate is distributed in a band-like pattern, symmetrically around the nevus, while in regressing primary melanoma it is asymmetric, surrounding only some segments of the tumor [ 33 ].…”

Section: The Microscopic Features—what Matters In Atypical Tumors?mentioning

confidence: 99%

Current Challenges in Deciphering Sutton Nevi—Literature Review and Personal Experience

Nedelcu

Dobre

Brînzea

et al. 2021

JPM

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Halo nevi, known as leukoderma acquisitum centrifugum, Sutton nevus, leukopigmentary nevus, perinevoid vitiligo, or perinevoid leukoderma, together with vitiligo and melanoma-associated hypopigmentation, belong to the group of dermatoses designated as immunological leukodermas. The etiology and pathogenesis of halo nevi has not been fully elucidated. There are several mechanisms through which a lymphocytic infiltrate can induce tumoral regression. In this review, we aimed to update the knowledge about Sutton nevi starting with the clinical appearance and dermoscopic features, continuing with information regarding conventional microscopy, immunohistochemistry, and the immunological mechanisms responsible for the occurrence of halo nevi. We also included in the article original unpublished results when discussing dermoscopic, pathologic and immunohistochemical results in halo nevi. Sutton nevi are valuable models for studying antitumor reactions that the human body can generate. The slow and effective mechanism against a melanocytic skin tumor can teach us important lessons about both autoimmune diseases and anticancer defenses.

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Eruptive halo nevi and new-onset vitiligo post-COVID-19 infection

Pastukhova¹,

Ghazawi²

2023

JAAD Case Reports

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Foxp3<sup>+</sup> Regulatory T Cells Are Increased in the Early Stages of Halo Nevi: Clinicopathological Features of 30 Halo Nevi

Cited by 3 publications

References 43 publications

Factors Associated with Development of Vitiligo in Patients with Halo Nevus

Factors Associated with Development of Vitiligo in Patients with Halo Nevus

Current Challenges in Deciphering Sutton Nevi—Literature Review and Personal Experience

Eruptive halo nevi and new-onset vitiligo post-COVID-19 infection

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