Despite the tremendous socioeconomic importance of supply chains (SCs), security officers and operators are faced with no easy and integrated way for protecting their critical, and interconnected, infrastructures from cyber-attacks. As a result, solutions and methodologies that support the detection of malicious activity on SCs are constantly researched into and proposed. Hence, this work presents the implementation of a low-cost reconfigurable intrusion detection system (IDS), on the edge, that can be easily integrated into SC networks, thereby elevating the featured levels of security. Specifically, the proposed system offers real-time cybersecurity intrusion detection over high-speed networks and services by offloading elements of the security check workloads on dedicated reconfigurable hardware. Our solution uses a novel framework that implements the Aho–Corasick algorithm on the reconfigurable fabric of a multi-processor system-on-chip (MPSoC), which supports parallel matching for multiple network packet patterns. The initial performance evaluation of this proof-of-concept shows that it holds the potential to outperform existing software-based solutions while unburdening SC nodes from demanding cybersecurity check workloads. The proposed system performance and its efficiency were evaluated using a real-life environment in the context of European Union’s Horizon 2020 research and innovation program, i.e., CYRENE.