Fracaso renal agudo anúrico persistente en paciente infectado con Plasmodium malariae: la importancia de la biopsia renal

Alexandru, Simona; Ortíz, Alberto; Picasso, M; Suarez, Laura García-Puente; Saico, Saúl Enrique Pampa; Sánchez, María Soledad Pizarro; Ortiz, Pablo Cannata; Barba, Raquel

doi:10.1016/j.nefro.2019.10.002

Cited by 1 publication

(1 citation statement)

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“…Under the KDIGO definition, AKI is a manifestation of severe P. falciparum malaria in both adults [ 331 ] and children [ 332 ], including in conjunction with severe malarial anaemia and cerebral malaria [ 332 ]. AKI has also been reported in P. vivax [ 331 , 333 ], P. knowlesi [ 333 ] and occasionally P. malariae [ 334 ]. AKI is associated with an increased duration of hospitalization and mortality [ 332 , 335 ] and potentially an increased risk of chronic kidney disease, particularly in children with cerebral malaria.…”

Section: Molecular Basis Of Severe Disease Phenotypes and Symptomsmentioning

confidence: 99%

Pathogenicity and virulence of malaria: Sticky problems and tricky solutions

Walker¹,

Rogerson

2023

Virulence

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Infections with Plasmodium falciparum and Plasmodium vivax cause over 600,000 deaths each year, concentrated in Africa and in young children, but much of the world’s population remain at risk of infection. In this article, we review the latest developments in the immunogenicity and pathogenesis of malaria, with a particular focus on P. falciparum , the leading malaria killer. Pathogenic factors include parasite-derived toxins and variant surface antigens on infected erythrocytes that mediate sequestration in the deep vasculature. Host response to parasite toxins and to variant antigens is an important determinant of disease severity. Understanding how parasites sequester, and how antibody to variant antigens could prevent sequestration, may lead to new approaches to treat and prevent disease. Difficulties in malaria diagnosis, drug resistance, and specific challenges of treating P. vivax pose challenges to malaria elimination, but vaccines and other preventive strategies may offer improved disease control.

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