Fractal Analysis of Ibuprofen Effect on Experimental Dog Peri-implantitis

Pârvu, Alina Elena; Ţălu, Ștefan; Taulescu, Marian; Bota, Andreea; Cătoi, Florinela Adriana; Crăciun, C.; Alb, Camelia; Parvu, Ovidiu; Alb, Sandu Florin

doi:10.1097/id.0000000000000065

Cited by 9 publications

(10 citation statements)

References 41 publications

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“…Inflammation was induced with turpentine oil (6 mL/kg b.w.) administered intramuscularly, in the animals treated with the extracts, as well as in the INFLAM and DICLO groups [ 24 ]. To the CONTROL animals, 0.9% saline was injected intramuscularly (i.m.).…”

Section: Methodsmentioning

confidence: 99%

Phytochemical Analysis of Anti‐Inflammatory and Antioxidant Effects of Mahonia aquifolium Flower and Fruit Extracts

Andreicut

Pârvu

Moţ

et al. 2018

Oxidative Medicine and Cellular Longevity

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Oxidative stress and inflammation are interlinked processes. The aim of the study was to perform a phytochemical analysis and to evaluate the antioxidant and anti-inflammatory activities of ethanolic Mahonia aquifolium flower (MF), green fruit (MGF), and ripe fruit (MRF) extracts. Plant extract chemical composition was evaluated by HLPC. A DPPH test was used for the in vitro antioxidant activity. The in vivo antioxidant effects and the anti-inflammatory potential were tested on a rat turpentine oil-induced inflammation, by measuring serum nitric oxide (NOx) and TNF-alpha, total oxidative status (TOS), total antioxidant reactivity (TAR), oxidative stress index (OSI), 3-nitrothyrosine (3NT), malondialdehyde (MDA), and total thiols (SH). Extracts were administrated orally in three dilutions (100%, 50%, and 25%) for seven days prior to inflammation. The effects were compared to diclofenac. The HPLC polyphenol and alkaloid analysis revealed chlorogenic acid as the most abundant compound. All extracts had a good in vitro antioxidant activity, decreased NOx, TOS, and 3NT, and increased SH. TNF-alpha was reduced, and TAR increased only by MF and MGF. MDA was not influenced. Our findings suggest that M. aquifolium has anti-inflammatory and antioxidant effects that support the use in primary prevention of the inflammatory processes.

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Section: Methodsmentioning

confidence: 99%

Phytochemical Analysis of Anti‐Inflammatory and Antioxidant Effects of Mahonia aquifolium Flower and Fruit Extracts

Andreicut

Pârvu

Moţ

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…) and stress (Parvu et al. ), systemic diseases such as diabetes (Gomez‐Moreno et al. ) and osteoporosis (Giro et al.…”

mentioning

confidence: 99%

Ligature induced peri‐implantitis: tissue destruction and inflammatory progression in a murine model

Jia

Chou

et al. 2016

Clinical Oral Implants Res

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“…Chronic inflammation is the substrate for degenerative diseases (Zhang and Tsao, 2016) and oxidative stress caused by ROS has a crucial role in those diseases (Shahidi and Ambigaipalan, 2015) (Pârvu et al, 2014). Flavonoids, phenolic acids, lignans, tocopherols and phospholipids are known to be natural antioxidant compounds (Shahidi and Ambigaipalan, 2015).…”

Section: Experimental Designmentioning

confidence: 99%

Mahonia Aquifolium Flowers Extract Effects in Acute Experimental Inflammation

Cecan¹,

Pârvu²,

Pârvu³

et al. 2018

BUASVMCN-FST

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Natural products were proved to have inhibitory effect on the nitro-oxidative stress. The aim of the study was to evaluate the effect of Mahonia aquifolium (MA) flowers extract upon nitro-oxidative stress in acute experimental inflammation. The extract was prepared by repercolation method. Acute experimental inflammation was induced with turpentine oil (0,6ml/kg b.w. i.m.). MA extract was given for 7 days. Were used 6 groups (n=5) of male Wistar rats: Groups 1-3 were with acute inflammation and treated with MA dilutions (100%, 50%, 25%); Group 4 was acute inflammation control; Group 5 was negative control; Group 6 was acute inflammation treated with diclofenac (10mg/kg b.w. p.o). In day 8 nitro-oxidative stress was evaluated by measuring serum nitrites and nitrates (NOx), Total oxidative stress (TOS), Total antioxidant capacity (TAC), Oxidative stress index (OSI), Malondialdehyde (MDA) and Thiols (SH). MA reduced OSI and TOS, increased SH, and had no important effect on TAC, NO and MDA. Compared to MA, Diclofenac was a stronger inhibitor of TOS and OSI, and had a smaller effect on SH. Mahonia aquifolium flowers extract had inhibitory effect on the oxidative stress, without influencing NO and lypoperoxides production, the effect being smaller than that of Diclofenac.

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Fractal Analysis of Ibuprofen Effect on Experimental Dog Peri-implantitis

Abstract: This study confirms that fractal analysis was a good method to assess the complex morphological changes and correlations with the nitro-oxidative stress in PI. Short-term low-dose IBU treatment consistently improved gingival status and reduced systemic nitro-oxidative stress.

Cited by 9 publications

References 41 publications

Phytochemical Analysis of Anti‐Inflammatory and Antioxidant Effects of Mahonia aquifolium Flower and Fruit Extracts

Phytochemical Analysis of Anti‐Inflammatory and Antioxidant Effects of Mahonia aquifolium Flower and Fruit Extracts

Ligature induced peri‐implantitis: tissue destruction and inflammatory progression in a murine model

Mahonia Aquifolium Flowers Extract Effects in Acute Experimental Inflammation

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