“…Objectively, this number is not high enough to fully generalize the results, and only evidence on stroke patients is available in reasonable number to extract preliminary generalizable results. In addition, the vast majority of studies ignored some pathological information (e.g., the type of lesion and position) when analyzing and interpreting muscle synergies [ 86 , 145 ], while in the literature it was shown that the severity of impairment [ 44 ] and the side of the stroke lesion [ 110 ] affects the structure of muscle synergies. These studies recruited patients with different impairment levels and at different stages of recovery, which further weakened the explanation of the results which was often addressed with subject-specific findings with limited generalization power.…”