Any physical laws are scale-dependent, the same phenomenon might lead to debating theories if observed using different scales. The two-scale thermodynamics observes the same phenomenon using two different scales, one scale is generally used in the conventional continuum mechanics, and the other scale can reveal the hidden truth beyond the continuum assumption, and fractal calculus has to be adopted to establish governing equations. Here basic properties of fractal calculus are elucidated, and the relationship between the fractal calculus and traditional calculus is revealed using the two-scale transform, fractal variational principles are discussed for 1-D fluid mechanics. Additionally planet distribution in the fractal solar system, dark energy in the fractal space, and a fractal ageing model are also discussed.