Fractal Dimension and Texture Analysis in the Assessment of Experimental Laser-Induced Periodic Surface Structures (LIPSS) Dental Implant Surface—In Vitro Study Preliminary Report

Hadzik, Jakub; Kubasiewicz−Ross, Paweł; Simka, Wojciech; Gębarowski, Tomasz; Barg, Ewa; Cieśla-Niechwiadowicz, Aneta; Szajna, Anna Trzcionka; Szajna, Ernest; Gedrange, Tomasz; Kozakiewicz, Marcin; Dominiak, Marzena; Jurczyszyn, Kamil

doi:10.3390/ma15082713

Cited by 13 publications

(12 citation statements)

References 24 publications

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“…The implant micro-surface and nano-surface modifications have been proven to affect cellular responses such as cell adhesion, proliferation, differentiation, and migration, thus influencing bone healing. Due to surface modifications, it was possible to overcome the adverse effects of length reduction and the unfavorable crown–implant ratio of short implants, shortening the time needed to achieve secondary stability and deliver prosthetic restoration [ 35 ]. The decontamination of the implant surface is also of fundamental importance.…”

Section: Discussionmentioning

confidence: 99%

Use of CGF in Oral and Implant Surgery: From Laboratory Evidence to Clinical Evaluation

Palermo

Giannotti

Stanca

et al. 2022

IJMS

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Edentulism is the condition of having lost natural teeth, and has serious social, psychological, and emotional consequences. The need for implant services in edentulous patients has dramatically increased during the last decades. In this study, the effects of concentrated growth factor (CGF), an autologous blood-derived biomaterial, in improving the process of osseointegration of dental implants have been evaluated. Here, permeation of dental implants with CGF has been obtained by using a Round up device. These CGF-coated dental implants retained a complex internal structure capable of releasing growth factors (VEGF, TGF-β1, and BMP-2) and matrix metalloproteinases (MMP-2 and MMP-9) over time. The CGF-permeated implants induced the osteogenic differentiation of human bone marrow stem cells (hBMSC) as confirmed by matrix mineralization and the expression of osteogenic differentiation markers. Moreover, CGF provided dental implants with a biocompatible and biologically active surface that significantly improved adhesion of endothelial cells on CGF-coated implants compared to control implants (without CGF). Finally, data obtained from surgical interventions with CGF-permeated dental implants presented better results in terms of optimal osseointegration and reduced post-surgical complications. These data, taken together, highlight new and interesting perspectives in the use of CGF in the dental implantology field to improve osseointegration and promote the healing process.

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Section: Discussionmentioning

confidence: 99%

Use of CGF in Oral and Implant Surgery: From Laboratory Evidence to Clinical Evaluation

Palermo

Giannotti

Stanca

et al. 2022

IJMS

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“…Culture reagents were purchased from Biological Industries (Beit-Haemek, Israel). Detailed methodology for the assessment of cell vitality is presented by Hadzik et al concerning experimental implant surfaces [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

An Experimental Anodized Titanium Surface for Transgingival Dental Implant Elements—Preliminary Report

Hadzik

Kubasiewicz−Ross²,

Gębarowski³

et al. 2023

JFB

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The characteristics such as microtopography, physical and chemical properties influence the behavior of an implant in a soft tissue. Anodization—as a potent method of titanium alloy surface modification—of the transgingival abutment or healing screw, has achieved some improvement. One of the possible surface treatment method is low-pressure radiofrequency oxygen plasma treatment. The aim of the study was to evaluate the chemical properties and cytocompatibility of the experimental surface. Titanium discs made of grade-23 titanium alloy (Ti-6Al-4V) anodized (A sample) with different voltage parameters (28, 67, 78, and 98 V) were included in the study. Half of the samples regarded as the “S” group were additionally treated with low-pressure radiofrequency oxygen plasma treatment. The surfaces were characterized using scanning electron microscopy, X-ray spectroscopy and Raman spectroscopy, and electrochemically investigated via a corrosion test. Furthermore, two cell lines were used, including the CHO-compatible reference line and a primary human fibroblast line for the MTT assay; direct (contact) cytotoxicity of the materials was tested with the cells, and the growth of fibroblasts on the surfaces of the different materials was tested. The morphology of the “S”-treated samples did not differ from the morphology of only-anodized samples. However, the oxygen concentration on the surface in that group slightly increased by about 1% as a result of post-trial treatment. The highest corrosion resistance was observed for both A-78 V and S-78 V samples. The cytotoxicity assay revealed no changes in cell morphology or vitality. The MTT test proved comparable culture viability among all groups; however, the “S” samples showed statistically significantly higher fibroblast proliferation and adhesion scores compared to the “A” samples. Through the in vitro study, the low-pressure radiofrequency oxygen plasma treatment of the anodized Ti-6Al-4V alloy presented itself as an auspicious option in the field of transgingival element surface modification of implants.

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“…Many clinical and radiographic evaluation methods have been developed for objective assessment of osseointegration (resonance frequency analysis, reverse torque analysis) [ 33 , 34 , 35 ]. Also, new experimental methods of texture and fractal dimension analyses seem promising in the evaluation of dental implants with complex geometry, but require further studies to further assess their reliability [ 36 ]. Therefore, one of the most objective techniques to evaluate implant surface performance is still the histomorphometric measurement and calculation of bone-implant contact (BIC) [ 37 , 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Nanostructured Calcium-Incorporated Surface Compared to Machined and SLA Dental Implants—A Split-Mouth Randomized Case/Double-Control Histological Human Study

et al. 2023

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Background: Implant surface topography is a key element in achieving osseointegration. Nanostructured surfaces have shown promising results in accelerating and improving bone healing around dental implants. The main objective of the present clinical and histological study is to compare, at 4 and 6 weeks, (w) bone-to-implant contact in implants having either machined surface (MAC), sandblasted, large grit, acid-etched implant surface (SLA) medium roughness surface or a nanostructured calcium-incorporated surface (XPEED®). Methods: 35 mini-implants of 3.5 × 8.5 mm with three different surface treatments (XPEED® (n = 16)—SLA (n = 13)—MAC (n = 6), were placed in the posterior maxilla of 11 patients (6 females and 5 males) then, retrieved at either 4 or 6w in a randomized split-mouth study design. Results: The BIC rates measured at 4w and 6w respectively, were: 16.8% (±5.0) and 29.0% (±3.1) for MAC surface; 18.5% (±2.3) and 33.7% (±3.3) for SLA surface; 22.4% (±1.3) and 38.6% (±3.2) for XPEED® surface. In all types of investigated surfaces, the time factor appeared to significantly increase the bone to implant contact (BIC) rate (p < 0.05). XPEED® surface showed significantly higher BIC values when compared to both SLA and MAC values at 4w (p < 0.05). Also, at 6w, both roughened surfaces (SLA and XPEED®) showed significantly higher values (p < 0.05) than turned surface (MAC). Conclusions: Nanostructured Calcium titanate coating is able to enhance bone deposition around implants at early healing stages.

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Fractal Dimension and Texture Analysis in the Assessment of Experimental Laser-Induced Periodic Surface Structures (LIPSS) Dental Implant Surface—In Vitro Study Preliminary Report

Cited by 13 publications

References 24 publications

Use of CGF in Oral and Implant Surgery: From Laboratory Evidence to Clinical Evaluation

Use of CGF in Oral and Implant Surgery: From Laboratory Evidence to Clinical Evaluation

An Experimental Anodized Titanium Surface for Transgingival Dental Implant Elements—Preliminary Report

Nanostructured Calcium-Incorporated Surface Compared to Machined and SLA Dental Implants—A Split-Mouth Randomized Case/Double-Control Histological Human Study

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