Fractal features of dual temperature/pH-sensitive poly(N-isopropylacrylamide-co-acrylic acid) hydrogels and resultant effects on the controlled drug delivery performances

Xu, Xiaohuan; Sun, Jihong; Bing, Liujie; Cui, Xueqing; Jia, Bingying; Bai, Shiyang

doi:10.1016/j.eurpolymj.2022.111203

Cited by 11 publications

(6 citation statements)

References 49 publications

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“…The normalized Kratky plots of P(NA-AA)−0−y were specifically presented in Figure S5A in the ESI section. Their signal intensities increased gradually in larger q -range ( q > 1) with an increase in the NA-doped amount, indicating that the conformation of P(NA-AA)−0−y appears to be abundant and dominated by partially unfolded states, similar to our previous report [ 33 ].…”

Section: Resultssupporting

confidence: 88%

Dispersion Performances and Fluorescent Behaviors of Naphthalic Anhydride Doped in Poly(acrylic acid) Frameworks for pH-Sensitive Ibuprofen Delivery via Fractal Evolution

Cui

Wang

et al. 2023

Polymers

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The pH-responsive fluorescent P(1,8-naphthalic anhydride (NA)-acrylic acid (AA)) matrix was successfully prepared by a doping method using poly(acrylic acid) (PAA) as a pH-sensitive polymer and NA as a fluorescent tracer. The fluorescent behaviors of the used NA dispersed in PAA frameworks were demonstrated based on fractal features combined with various characterizations, such as small-angle X-ray scattering (SAXS) patterns, photoluminescence (PL) spectra, scanning electron microscope (SEM) images, thermogravimetry (TG) profiles, Fourier transform infrared (FT-IR) spectroscopy, and time-resolved decays. The effects of NA-doping on the representative fluorescent P(NA-AA) were investigated, in which the fluorescent performance of the doped NA was emphasized. The results indicated that aggregated clusters of the doped NA were gradually serious with an increase in NA doping amount or extension of NA doping time, accompanied by an increase in mass fractal dimension (Dm) values. Meanwhile, the doped NA presented stable fluorescent properties during the swelling–shrinking process of PAA. Ibuprofen (IBU) was used as a model drug, and fractal evolutions of the obtained P(NA-AA) along with the drug loading and releasing behaviors were evaluated via SAXS patterns, in which the drug-loaded P(NA-AA) presented surface fractal (Ds) characteristics, while the Dm value varied from 2.94 to 2.58 during sustained drug-release in pH 2.0, indicating occurrences of its structural transformation from dense to loose with extension of IBU-releasing time. Finally, the cytotoxicity and cellular uptake behaviors of the obtained P(NA-AA) were preliminarily explored. These demonstrations revealed that the resultant P(NA-AA) should be a potential intelligent-responsive drug carrier for targeted delivery.

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Section: Resultssupporting

confidence: 88%

Dispersion Performances and Fluorescent Behaviors of Naphthalic Anhydride Doped in Poly(acrylic acid) Frameworks for pH-Sensitive Ibuprofen Delivery via Fractal Evolution

Cui

Wang

et al. 2023

Polymers

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“…However, the percentage release of ibuprofen did not exceed 50% at pH 7.4 and did not exceed 70% at pH 2.0. In contrast to [ 102 ], in [ 103 ], the percentage of ibuprofen release from a porous hydrogel based on a copolymer of N-isopropylacrylamide and crotonic acid was more than 50% at pH 6.8, but not more than 11% in a 0.1 M HCl solution.…”

Section: Gels For the Delivery Of Antimicrobial And Antipyretic Drugsmentioning

confidence: 71%

“…pH and temperature-sensitive gels of copolymers of acrylic acid and N-isopropylacrylamide, having a porous structure and a degree of swelling in the water of approximately 11,000%, is a promising means of delivering ibuprofen. This was evidenced by the data of modeling the adsorption-diffusion of ibuprofen from the gel matrix [ 102 ]. However, the percentage release of ibuprofen did not exceed 50% at pH 7.4 and did not exceed 70% at pH 2.0.…”

Section: Gels For the Delivery Of Antimicrobial And Antipyretic Drugsmentioning

confidence: 99%

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

et al. 2023

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Modified polymeric gels, including nanogels, which play not only the role of a bioinert matrix, but also perform regulatory, catalytic, and transport functions due to the active fragments introduced into them, can significantly advance the solution to the problem of targeted drug delivery in an organism. This will significantly reduce the toxicity of used pharmaceuticals and expand the range of their therapeutic, diagnostic, and medical application. This review presents a comparative description of gels based on synthetic and natural polymers intended for pharmaceutical-targeted drug delivery in the field of therapy of inflammatory and infectious diseases, dentistry, ophthalmology, oncology, dermatology, rheumatology, neurology, and the treatment of intestinal diseases. An analysis was made of most actual sources published for 2021–2022. The review is focused on the comparative characteristics of polymer gels in terms of their toxicity to cells and the release rate of drugs from nano-sized hydrogel systems, which are crucial initial features for their further possible application in mentioned areas of biomedicine. Different proposed mechanisms of drug release from gels depending on their structure, composition, and application are summarized and presented. The review may be useful for medical professionals, and pharmacologists dealing with the development of novel drug delivery vehicles.

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“…Therefore, hydrogels are widely regarded as suitable candidates in diverse fields including wearable strain sensors, 1−3 implanted energy harvesting and storage devices, 4−6 flexible electronic skins, 7−9 and biomedicine. 10,11 Alginate, a natural anionic copolymer derived generally from seaweed, is frequently used to fabricate biobased hydrogels, because of its good biocompatibility, controllable biodegradability, and environmental sustainability. 10,12−20 The main chain of alginate is configured by (1−4)-linked β-mannuronic acid (M monomer) and α-guluronic acid (G monomer), where the M monomer and G monomer are arranged repeatedly (MM or GG) or alternately (MG).…”

Section: Introductionmentioning

confidence: 99%

“…Hydrogels are a kind of soft materials comprising a three-dimensional (3D) cross-linked network, which serves as the supporting scaffold, and a large amount of water trapped inside, greatly resembling biological tissues like skin, muscles, and cartilage. Therefore, hydrogels are widely regarded as suitable candidates in diverse fields including wearable strain sensors, − implanted energy harvesting and storage devices, − flexible electronic skins, − and biomedicine. , …”

Section: Introductionmentioning

confidence: 99%

Multiple Physical Bonds Cross-Linked Strong and Tough Hydrogel with Antibacterial Ability for Wearable Strain Sensor

Zou

Chang

Liu

et al. 2022

ACS Appl. Polym. Mater.

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Strong, tough, and antibacterial hydrogels are promising in the fields of human motion detection and wearable electronics. However, it remains challenging to reach the antibacterial ability without losing the mechanical properties. In this work, strong and tough Fe3+-sodium alginate/poly(acrylamide-co-acrylic acid)/Ag nanowire (Fe3+-SA/P(Am-co-Ac)/AgNWs) hydrogel with antibacterial ability was facially prepared using multiple physical bonds. The superior mechanical properties are ensured by the double network matrix and well-designed interface between the matrix and AgNWs. The antibacterial ability was realized by the introduction of AgNWs. The matrix contains the Fe3+-SA network and the Fe3+-P(Am-co-Ac) network, which are further united together via the shared Fe3+ based ionic interaction. The interfacial defects between AgNWs and the organic matrix were efficiently eliminated by the incorporation of bis (acryloyl)cystamine (BACA) as “bridge” molecules: the CC bond on BACA was grafted onto the main chain of P(Am-co-Ac) by free radical polymerization, and the S–S bond on BACA was anchored onto the surface of AgNWs through the Ag–S metal ligand effect. Benefiting from the multiple physical bonds and well-designed interface, the as-prepared hydrogel exhibited a stretching strength of 3.87 MPa, an elongation at break of 3127%, and a fracture energy of 112.32 MJ m–3. The bacteriostatic ratio of the as-prepared hydrogel against E. coli and S. aureus bacteria was as high as 99.98% and 99.95%. Moreover, the hydrogel displayed a conductivity and strain sensitivity (GF) of 0.01 and 0.59, a broad working range of 0–500%, and 500 cycles of loading–unloading under a strain of 40%, enabling the hydrogel to be sensitive on a large scale and with subtle body movements and making hydrogel the perfect strain sensor to monitor various human motions.

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Fractal features of dual temperature/pH-sensitive poly(N-isopropylacrylamide-co-acrylic acid) hydrogels and resultant effects on the controlled drug delivery performances

Cited by 11 publications

References 49 publications

Dispersion Performances and Fluorescent Behaviors of Naphthalic Anhydride Doped in Poly(acrylic acid) Frameworks for pH-Sensitive Ibuprofen Delivery via Fractal Evolution

Dispersion Performances and Fluorescent Behaviors of Naphthalic Anhydride Doped in Poly(acrylic acid) Frameworks for pH-Sensitive Ibuprofen Delivery via Fractal Evolution

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

Multiple Physical Bonds Cross-Linked Strong and Tough Hydrogel with Antibacterial Ability for Wearable Strain Sensor

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