The manufacturing difficulties of complex fractal-tree-like heat exchangers have limited their industrial applications, although many evidences have shown that they have significant advantages in heat transfer. Nevertheless, the emerging 3D printing technology has brought great opportunity for the development of complex structured device. In the present study, three-dimensional (3D) fractal-tree-like heat exchangers were designed and manufactured using 3D printing technology. Their performance was evaluated from both thermal and hydrodynamic perspectives, the flow characteristics were investigated in detail. The results show that a fractal-tree-like heat exchanger can improve hydrodynamic performance, reduce pressure drops and has great heat transfer ability. In general, the fractal-tree-like heat exchanger has a comprehensive advantage over the traditional spiral-tube exchangers as it has a higher value of coefficient of performance (COP). Furthermore, the 3D printing provides a visual, efficient, and precise approach in the present research.