“…With recent advances, they can now obtain key diagnostic information about the chemical and/or biomolecular compositions, such as intestinal gas profiles related to gut microbial fermentative activities, biomarkers of thiosulfate and acyl-homoserine lactone, and GI bleeding . By integrating them with medicines, the electromagnetic field generated from them can monitor medication adherence. , In addition, drug release at intended positions can be monitored with a pH-triggered switch or by inserting ingestible tips into the stomach lining in a drug delivery system. , To achieve safe sensing with less attenuation, radio frequencies of 420–450 MHz (IEEE 802.15.6 standard), 433 MHz (accepted by FDA), and 900 MHz are commonly used for medical devices. − As a simple and costless method that does not necessarily require a power supply, devices operating at 13.56 MHz are also attracting attention. , Although they can transmit unique in-body data, some devices for patients with bowel disease showed 1.4% retention in the GI tract due to their size and required surgery for removal. To improve the safety, changes in materials are required, and the development of completely new devices consisting of edible electronic components is eagerly anticipated. − …”