Fractalkine in the peritoneal fluid of women with endometriosis

Shimoya, Koichiro; Zhang, Q.; Temma-Asano, Kumiko; Hayashi, Shunsuke; Kimura, Toshihiro; Murata, Yuji

doi:10.1016/j.ijgo.2005.06.018

Cited by 14 publications

(13 citation statements)

References 22 publications

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“…Furthermore, the size of the residual tumor after debulking surgery plays a significant role in determining patient survival (47). Our data and previously published results show that high levels of CX 3 CL1 are present in the peritoneal milieu in the ascites of patients with various malignant and non-malignant gynecologic diseases (Table 1, (42)). Therefore, we hypothesized that CX 3 CL1 could induce the proliferation of EOC cells.…”

Section: Resultssupporting

confidence: 84%

“…Peritoneal ascites is a rich source of many compounds, including growth factors, components of the extracellular matrix, and chemokines. Soluble CX 3 CL1 is present in the low nanomolar range in the ascites of women with endometriosis (42). We therefore measured CX 3 CL1 levels in the ascites of women with EOC and women with borderline gynecologic conditions.…”

Section: Resultsmentioning

confidence: 99%

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Fractalkine Receptor CX3CR1 Is Expressed in Epithelial Ovarian Carcinoma Cells and Required for Motility and Adhesion to Peritoneal Mesothelial Cells

Kim

Rooper

Xie

et al. 2012

Molecular Cancer Research

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Epithelial ovarian carcinoma is a deadly disease, and little is known about the mechanisms underlying its metastatic progression. Using human specimens and established cell lines, we determined that the G protein-coupled seven-transmembrane fractalkine receptor (CX3CR1) is expressed in primary and metastatic ovarian carcinoma cells. Ovarian carcinoma cells robustly migrated toward CX3CL1, a specific ligand of CX3CR1, in a CX3CR1-dependent manner. Silencing of CX3CR1 reduced migration toward human ovarian carcinoma ascites fluid by approximately 70%. Importantly, adhesion of ovarian carcinoma cells to human peritoneal mesothelial cells was dependent on CX3CL1/CX3CR1 signaling. In addition, CX3CL1 was able to induce cellular proliferation. Together, our data suggest that the fractalkine network may function as a major contributor to the progression of epithelial ovarian carcinoma, and further attention to its role in the metastasis of this deadly malignancy is warranted.

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Section: Resultssupporting

confidence: 84%

Section: Resultsmentioning

confidence: 99%

Fractalkine Receptor CX3CR1 Is Expressed in Epithelial Ovarian Carcinoma Cells and Required for Motility and Adhesion to Peritoneal Mesothelial Cells

Kim

Rooper

Xie

et al. 2012

Molecular Cancer Research

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“…Fractalkine (CX3CL1) is a member of a third family of chemokines, wherein three amino acids separate the two canonical cysteines. In a single report that described fractalkine in the peritoneal fluid of women with endometriosis, its concentrations were lower than in control samples (Shimoya et al, 2005). This chemokine was noted to be present in endometrial epithelium and stroma, with the latter prominent in the secretory phase of the normal cycle and further stimulated after therapeutic treatment with progestogen contraceptives (Hannan et al, 2004).…”

Section: Cx3c Chemokinesmentioning

confidence: 97%

Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis

Reis

Petraglia

Taylor

2013

Human Reproduction Update

227

172

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Estrogens and progestogens modulate chemotaxis and apoptosis in human endometrium and endometriotic cells and tissues. These endocrine and paracrine pathways are perturbed in women with endometriosis, contributing to inflammatory responses, abnormal tissue remodeling, therapeutic refractoriness and disease persistence. Ultimately, they promote adhesion formation and the clinical symptoms of pelvic pain and infertility. A more detailed understanding of the molecular mechanisms involved will offer new opportunities for novel pharmacological strategies to diagnose and treat endometriosis.

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“…A atividade das células NK pode ser modulada pela presença de algumas quimiocinas . Seja pelo aumento da migração destas células em resposta à presença de determinadas quimiocinas (CXCL 9, 10, 11 e 12, XCL1 e CX3CL1), como pelo aumento de sua atividade citolítica quando na presença de quimiocinas específicas (CXCL10 e CX3CL1) Moris and Ley, 2004;Groom and Luster, 2011 A CX3CL1 (Fraktalkine) é uma das quimiocinas mais estudadas em endometriose Shimoya et al, 2005;Watanabe et al, 2006;. Watanabe et al, 2006 A endometriose é uma entidade em estudo e que muitas dúvidas ainda pairam no ar.…”

Section: Discussionunclassified

“…The differences in the levels of some of the chemokines found in our study highlights the defective action of NK cells in patients with endometriosis. CX3CL1 (fractalkine) is one of the most studied chemokines in endometriosis (29,(45)(46)(47). Watanabe et al (47) evaluated healthy women and showed that CX3CL1 is present to a greater extent in eutopic endometrium in the secretory phase of the cycle compared with the proliferative phase.…”

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confidence: 99%

Expressão de quimiocinas regulatórias das células Natural Killer e T-reguladoras em pacientes com endometriose profunda

Bellelis¹

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Objective: Endometriosis is a highly prevalent inflammatory condition associated with an altered immune response in the peritoneal cavity and uterus. Evidence suggests a participation of inflammatory mediators such as natural killer (NK) and T-regulatory (T-reg) cells in the pathogenesis of this disease while the response of these cells may be controlled by the activity of some chemokines. Patients and Methods: Gene expressions of the chemokines that regulate the activity of NK (CXCL9, CXCL10, CXCL11, CXCL12, XCL1 and CX3CL1) and T-reg cells (CCL17 and CCL21) were evaluated using real time polymerase chain reaction (PCR) in the eutopic and ectopic endometrium of 22 patients with bowel endometriosis, 10 patients with retrocervical endometriosis and 32 controls. Results: Of the chemokines associated with NK cells, the expression of CX3CL1 and CXCL12 was significantly greater in the foci of endometriosis (p<0.05). Of those associated with T-reg cells, significant differences between groups were found in CCL17. In addition, CCL17 was expressed to a higher degree in the eutopic endometrium of the patients with rectosigmoid lesions when compared to the other groups (p<0.05). Conclusions: Chemokines CX3CL1 and CXCL12 were more expressed in intestinal endometriosis and CCL17 expression was higher in eutopic endometrium of the patients with rectosigmoid lesions. These results suggest that those chemokines participate in the inflammatory response that occurs in pelvic endometriosis.

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Fractalkine in the peritoneal fluid of women with endometriosis

Abstract: The decreased level of fractalkine found in the peritoneal fluid of patients with endometriosis may contribute to the pathogenesis of endometriosis.

Cited by 14 publications

References 22 publications

Fractalkine Receptor CX3CR1 Is Expressed in Epithelial Ovarian Carcinoma Cells and Required for Motility and Adhesion to Peritoneal Mesothelial Cells

Fractalkine Receptor CX3CR1 Is Expressed in Epithelial Ovarian Carcinoma Cells and Required for Motility and Adhesion to Peritoneal Mesothelial Cells

Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis

Expressão de quimiocinas regulatórias das células Natural Killer e T-reguladoras em pacientes com endometriose profunda

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