Fraction of Exhaled Nitric Oxide (Fe_NO) Norms in Healthy Tunisian Adults

Abstract

Aims. To establish FeNO norms for healthy Tunisian adults aged 18–60 years and to prospectively assess their reliability. Methods. This was a cross-sectional analytical study. A convenience sample of healthy Tunisian adults was recruited. Subjects responded to a medical questionnaire, and then FeNO levels were measured by an online method (Medisoft, Sorinnes (Dinant), Belgium). Clinical, anthropometric, and plethysmographic data were collected. All analyses were performed on natural logarithm values of FeNO. Results. 257 adults (145 males) were retained. The proposed reference equation to predict FeNO value is lnFeNO (ppb) = 3.47−0.56× height (m). After the predicted FeNO value for a given adult was computed, the upper limit of normal could be obtained by adding 0.60 ppb. The mean ± SD (minimum-maximum) of FeNO (ppb) for the total sample was 13.54 ± 4.87 (5.00–26.00). For Tunisian and Arab adults of any age and height, any FeNO value greater than 26.00 ppb may be considered abnormal. Finally, in an additional group of adults prospectively assessed, we found no adult with a FeNO higher than 26.00 ppb. Conclusion. The present FeNO norms enrich the global repository of FeNO norms that the clinician can use to choose the most appropriate norms.

Oxidative stress and lung function profiles of male smokers free from COPD compared to those with COPD: a case-control study

“…In addition, correlations between Fe NO values and the above plethysmographic parameters were also evaluated. In a recent study, done on Tunisian healthy non-smoking adult males, Fe NO values were not correlated with plethysmographic data ( 29 ) and to the best of our knowledge, no study has evaluated the correlation between smokers’ Fe NO and lung volumes, such as TLC or RV.…”

“…The smoker must have stopped smoking for at least 6 h ( 15 , 28 ) and was asked to fast (no eating or drinking) for at least 10 h before coming to the hospital. Subjects were asked to not participate in strenuous activity for 1 h prior to the fractional exhaled nitric oxide (Fe NO ) measurements ( 29 ).…”

Elevated nitric oxide and carbon monoxide concentration in nasal-paranasal sinus air as a diagnostic tool of migraine: a case – control study

“…Finally, the level of exhaled NO and oral CO content in exhaled air were recorded by the analyzers. Normal value of Fraction of Exhaled Nitric Oxide (FeNO) for Tunisian and Arab of adults of any age and height was 5- 26 ppb [ 12 ] and 5-17 ppb For North African, Arab children of any age [ 13 ]. Thus, 5-10 ppb was assumed and taken as the normal exhaled NO for adolescents in our study, as there is no reference range for Sri Lankan adolescents of any age.…”

An Evidence-Based Review of Application Devices for Nitric Oxide Concentration Determination from Exhaled Air in the Diagnosis of Inflammation and Treatment Monitoring

“…It has 3 test modes: bronchial with a flow rate of 50 mL/s, nasal with a sample flow rate of 100 mL/s, and alveolar with various flow rates (50, 100, and 150 mL/s). Values such as exhaled NO (ppb), exhaled air flow (L/min), and NO to exhaled flow (ml/min) and mean expiratory pressure (cm H 2 O) are obtained [24].…”