Fractional anisotropy and peripheral cytokine concentrations in outpatients with depressive episode: a diffusion tensor imaging observational study

Sammer, Gebhard; Neumann, Elena; Blecker, Carlo R.; Pedraz-Petrozzi, Bruno

doi:10.1038/s41598-022-22437-0

Cited by 5 publications

References 69 publications

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Correlation of White Matter Microstructure MRI and Inflammatory Cytokine Alterations With Symptom Severity in Premenstrual Syndrome

Duan,

Qin,

Lai

et al. 2024

Magnetic Resonance Imaging

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BackgroundWomen with premenstrual syndrome (PMS) are at increased risk for depression throughout their lives. White matter (WM) microstructure and inflammatory cytokine alterations have been proposed in its etiology.PurposeTo investigate whether WM, assessed using diffusion tensor imaging (DTI), and inflammatory cytokine levels are altered in PMS, and to examine the relationships between WM microstructure, inflammatory cytokines, and symptom severity.Study TypeProspective.SubjectsForty‐two PMS patients and 58 healthy controls (HCs), categorized according to the daily record of severity of problems (DRSP).Field Strength/Sequence3‐T, echo planar imaging DTI.AssessmentFractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were measured by using tract‐based spatial statistics (TBSS). Venous blood was collected to measure cytokines, including interleukin‐1β (IL‐1β) and tumor necrosis factor‐α (TNF‐α). Symptoms were assessed by using the DRSP.Statistical TestsTwo‐sample t test or Mann–Whitney U test were used to compare the DRSP and cytokines. Abnormal DTI metrics in WM were extracted and the differences between groups were analyzed by using two sample t‐tests. Spearman's correlation (r) was used to assess the relationship between DTI metrics, cytokines, and DRSP. A P‐value <0.05 with FDR correction was considered statistically significant.ResultsCompared with HCs, PMS patients showed significantly lower FA in the corpus callosum and corona radiata, and significantly higher MD, AD, and RD in the corticospinal tract (CST), and significantly higher MD and RD in the anterior thalamic radiation (ATR). These differential metrics were significantly correlated with DRSP. Patients showed significantly higher IL‐1β and TNF‐α than HCs. Moreover, TNF‐α correlated positively with MD, AD, and RD in both groups (r range, 0.256–0.315).Data ConclusionAlterations of WM microstructure and IL‐1β and TNF‐α may be associated with PMS symptom severity, and TNF‐α may correlate with DTI metrics of CST and ATR pathways.Evidence Level1Technical EfficacyStage 2

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Correlation of White Matter Microstructure MRI and Inflammatory Cytokine Alterations With Symptom Severity in Premenstrual Syndrome

Duan,

Qin,

Lai

et al. 2024

Magnetic Resonance Imaging

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Connectivity in the Dorsal Visual Stream is Enhanced in Action Video Game Players

Cahill,

Jordan,

Dhamala

2024

Preprint

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Action video games foster competitive environments that demand rapid spatial navigation and decision-making. Action video gamers often exhibit faster response times and slightly improved accuracy in vision-based sensorimotor tasks. However, the underlying functional and structural changes in the two visual streams of the brain that may be contributing to these cognitive improvements have been unclear. Using functional and diffusion MRI data, this study investigated the differences in connectivity between gamers who play action video games and nongamers in the dorsal and ventral visual streams. We found that action video gamers have enhanced functional and structural connectivity, especially in the dorsal visual stream. Specifically, there is heightened functional connectivity both undirected and directed between the left Superior Occipital Gyrus and the left Superior Parietal Lobule during a moving-dots discrimination decision-making task. This increased connectivity correlates with response time in gamers. The structural connectivity, as quantified by diffusion fractional anisotropy and quantitative anisotropy measures of the axonal fiber pathways between the same regions was also enhanced for gamers compared to nongamers. These findings provide valuable insights into how action video gaming can induce targeted neuroplastic changes, enhancing structural and functional connectivity between specific brain regions in the visual processing pathways. These connectivity changes in the dorsal visual stream underpin the superior performance of action video gamers compared to non-gamers in tasks requiring rapid and accurate vision-based decision-making.

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Peripheral blood cytokines as markers of longitudinal recovery in white matter microstructure following inpatient treatment for opioid use disorders

Butelman,

Huang,

King

et al. 2024

Preprint

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Background: Heroin and other opioid use disorders (HUD and OUD) cause major public health morbidity and mortality. Although standard-of-care medication assisted treatment (MAT) exists, little is known about potential predictors of change during recovery. Recovery can include normalization of brain white matter (WM) microstructure, which is sensitive to cytokine and immune signaling. Here we aimed to determine whether blood-based serum cytokine/immune levels can be markers of WM microstructure recovery following MAT. Methods: Inpatient Individuals with HUD (iHUD; n=21) and healthy controls (HC; n=24) underwent magnetic resonance scans with diffusion tensor imaging (DTI) and provided ratings of drug cue-induced craving, arousal and valence twice, earlier in treatment and ≈14 weeks of inpatient MAT (with methadone or buprenorphine) thereafter. At this second session (MRI2), they also provided a peripheral blood sample for multiplex relative quantification of serum cytokine/immune proteins (with a proximity extension assay, Olink). We explored the correlation of a multi-target cytokine biomarker score (based on principal component analysis of 19 proteins that differed significantly between iHUD and HC) with change in whole-brain DTI (ΔDTI; MRI2 - MRI1) metrics (fractional anisotropy, mean diffusivity, and axial diffusivity) across the 14 weeks of MAT. Results: The cytokine biomarker score, obtained at the MRI2 stage, was correlated with ΔDTI metrics in frontal, fronto-parietal, and cortico-limbic WM tracts (e.g., including the genu of the corpus callosum, anterior corona radiata, and others). In a follow-up analysis, specific cytokines represented in the multi-target biomarker score, such as the interleukin-related oncostatin M (OSM), colony-stimulating factor (CSF1), and the chemokine CCL7 were correlated with similar ΔDTI metrics in iHUD, but not in HC. Levels of other specific cytokines (i.e., CCL19 and CCL2) were negatively correlated with change in cue-induced craving or arousal. Thus, lower levels of the aforementioned cytokines were correlated with an increase in cue-induced craving or arousal across the two stages (MRI2 - MRI1). Conclusions: Studied as a multi-target biomarker score, or as selected individual targets, peripheral serum cytokines are highly accessible biomarkers of WM microstructure recovery in iHUD undergoing inpatient MAT.

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Fractional anisotropy and peripheral cytokine concentrations in outpatients with depressive episode: a diffusion tensor imaging observational study

Cited by 5 publications

References 69 publications

Correlation of White Matter Microstructure MRI and Inflammatory Cytokine Alterations With Symptom Severity in Premenstrual Syndrome

Correlation of White Matter Microstructure MRI and Inflammatory Cytokine Alterations With Symptom Severity in Premenstrual Syndrome

Connectivity in the Dorsal Visual Stream is Enhanced in Action Video Game Players

Peripheral blood cytokines as markers of longitudinal recovery in white matter microstructure following inpatient treatment for opioid use disorders

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