Fractional CO<sub>2</sub> laser‐assisted scar regeneration and repair: A review

Lei, Ying; Gold, Michael H.; Ouyang, Huawei; Tan, Jun

doi:10.1002/der2.61

Cited by 3 publications

(4 citation statements)

References 5 publications

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“…In another study, the PDL and fractional CO 2 lasers were equally effective in the treatment of hypertrophic scars 11 . In the experimental study, the authors found that VEGF expression in the composited laser group was weaker than that in the PDL group and fractional CO 2 group at 7 days, 14 days, and 28 days after treatment, with significant differences between the groups 37,39 . Fractional CO 2 laser can increase the apoptosis of fibroblasts, promote collagen degradation, and reduce the secretion of VEGF by epidermal cells, so as to inhibit the proliferation of microvessels and promote the maturation and vascular regression of hypertrophic scar 40–42 .…”

Section: Discussionmentioning

confidence: 98%

“…11 In the experimental study, the authors found that VEGF expression in the composited laser group was weaker than that in the PDL group and fractional CO 2 group at 7 days, 14 days, and 28 days after treatment, with significant differences between the groups. 37,39 Fractional CO 2 laser can increase the apoptosis of fibroblasts, promote collagen degradation, and reduce the secretion of VEGF by epidermal cells, so as to inhibit the proliferation of microvessels and promote the maturation and vascular regression of hypertrophic scar. [40][41][42] In our previous studies, we also demonstrated that PDL combined with fractional CO 2 laser could effectively treat fresh red hypertrophic scars in adults with no severe side effects.…”

Section: Posasmentioning

confidence: 99%

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Efficacy of pulsed dye laser combined with fractional CO₂ laser in the treatment of pediatric burn scars

et al. 2023

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Objective: The present study aimed to investigate the efficacy and safety of pulsed dye laser (PDL) combined with fractional CO 2 laser in the treatment of burn scars in pediatric patients. Methods: The present retrospective study enrolled 60 pediatric patients with burn scars from July 2017 to June 2021. In the 4-month treatment period, all patients received PDL treatment every 1 month and received fractional CO 2 laser treatment every 3 months. The Patient and Observer Scar Assessment Scale (POSAS) was used to evaluate the scar condition before the treatment as well as 6 months after the whole treatment. The satisfaction of the patient's parents was collected and recorded 6 months after the treatment. Complications were recorded during the treatment period and at follow-up visits.Results: Among all patients, 38 (63.33%) cases were scald-induced scars and 22 (36.67%) cases were burn-induced scars. The mean diameter of the scar area was 107.53 ± 2.92 cm 2 . For the measurement of the patient part of POSAS, all indices of pain, itching, color, stiffness, thickness, and irregularity, as well as the total scores were remarkably lower after 6 months of the treatment compared with the baseline (p < 0.05). For the observer part of POSAS, the indices of vascularization, pigmentation, thickness, relief, pliability, and surface area, as well as the total scores were markedly decreased after treatment (p < 0.05). The total satisfactory rate was 96.67% (58/60). No severe complications nor scar aggravation was observed. Conclusion:The combination of PDL and fractional CO 2 laser showed good efficacy in the treatment of pediatric patients with burn scars with no severe complications and can be recommended in clinical application.

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Section: Discussionmentioning

confidence: 98%

Section: Posasmentioning

confidence: 99%

Efficacy of pulsed dye laser combined with fractional CO₂ laser in the treatment of pediatric burn scars

et al. 2023

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“…Ablative lasers used clinically for resurfacing and matrix remodeling [25,26] have been used in other in vitro engineered skin models. A fractional erbium:YAG laser was used by Schmitt et al to study the molecular effects of ablative laser treatment in a cultured skin equivalent [27].…”

Section: Introductionmentioning

confidence: 99%

Laser Micropatterning Promotes Rete Ridge Formation and Enhanced Engineered Skin Strength without Increased Inflammation

et al. 2023

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Rete ridges play multiple important roles in native skin tissue function, including enhancing skin strength, but they are largely absent from engineered tissue models and skin substitutes. Laser micropatterning of fibroblast-containing dermal templates prior to seeding of keratinocytes was shown to facilitate rete ridge development in engineered skin (ES) both in vitro and in vivo. However, it is unknown whether rete ridge development results exclusively from the microarchitectural features formed by ablative processing or whether laser treatment causes an inflammatory response that contributes to rete ridge formation. In this study, laser-micropatterned and non-laser- treated ES grafts were developed and assessed during culture and for four weeks post grafting onto full-thickness wounds in immunodeficient mice. Decreases in inflammatory cytokine secretion were initially observed in vitro in laser-treated grafts compared to non-treated controls, although cytokine levels were similar in both groups five days after laser treatment. Post grafting, rete ridge-containing ES showed a significant increase in vascularization at week 2, and in collagen deposition and biomechanics at weeks 2 and 4, compared with controls. No differences in inflammatory cytokine expression after grafting were observed between groups. The results suggest that laser micropatterning of ES to create rete ridges improves the mechanical properties of healed skin grafts without increasing inflammation.

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“…Excessive scarring is divided into hypertrophic or keloid scarring. They both tend to be raised above skin level with keloids representing a fibroproliferative condition extending into normal adjacent skin and continuing to be elevated while hypertrophic scars are commonly limited to wound areas and can regress by time 3 …”

Section: Introductionmentioning

confidence: 99%

Update on management of keloid and hypertrophic scars: A systemic review

Elsaie

2021

J of Cosmetic Dermatology

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Numerous therapeutic strategies have been described for prevention and reduction of hypertrophic scars and keloids, but none of the treatments is effective in all patients. No universal consensus in treatment regimen has been established, and there is limited evidence‐based literature to guide the correct management. The process of scar development is complex and requires deeper understanding of the molecular mechanisms that cause their development and recurrences. Despite many available modes of targeting keloid and hypertrophic scars, yet they remain an ongoing challenge to patients and clinicians. To date, no one therapy has been universally accepted as the gold standard for the treatment of all excessive scars nor has the capability of complete scar resolution The search of literature included peer‐reviewed articles including clinical trials and scientific reviews. Literature was identified from electronic databases (MEDLINE/PubMed) through May 2021 and references of respective articles and only the articles published in English language were included.

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Fractional CO₂ laser‐assisted scar regeneration and repair: A review

Cited by 3 publications

References 5 publications

Efficacy of pulsed dye laser combined with fractional CO₂ laser in the treatment of pediatric burn scars

Efficacy of pulsed dye laser combined with fractional CO₂ laser in the treatment of pediatric burn scars

Laser Micropatterning Promotes Rete Ridge Formation and Enhanced Engineered Skin Strength without Increased Inflammation

Update on management of keloid and hypertrophic scars: A systemic review

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Fractional CO2 laser‐assisted scar regeneration and repair: A review

Cited by 3 publications

References 5 publications

Efficacy of pulsed dye laser combined with fractional CO2 laser in the treatment of pediatric burn scars

Efficacy of pulsed dye laser combined with fractional CO2 laser in the treatment of pediatric burn scars

Laser Micropatterning Promotes Rete Ridge Formation and Enhanced Engineered Skin Strength without Increased Inflammation

Update on management of keloid and hypertrophic scars: A systemic review

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Product

Resources

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Fractional CO₂ laser‐assisted scar regeneration and repair: A review

Efficacy of pulsed dye laser combined with fractional CO₂ laser in the treatment of pediatric burn scars

Efficacy of pulsed dye laser combined with fractional CO₂ laser in the treatment of pediatric burn scars