Fractional exhaled nitric oxide in asthma: an update

Sandrini, Alessandra; Taylor, D. Robin; Thomas, Paul S.; Yates, Deborah H

doi:10.1111/j.1440-1843.2009.01616.x

Cited by 70 publications

(64 citation statements)

References 171 publications

(350 reference statements)

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“…Healthy adults can exhibit values between 5-35 parts per billion at the standard flow rate of 50 ml/s (32,33) . The elevated levels of NO in expired air in asthmatics are indicative of eisonophilic inflammation; however, a direct pathogenic role of this gas in asthma is yet to be fully established (34)(35)(36) .…”

Section: Asthma Pathophysiologymentioning

confidence: 99%

n-3 Fatty acids and asthma

2016

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Asthma is one of the most common and prevalent problems worldwide affecting over 300 million individuals. There is some evidence from observational and intervention studies to suggest a beneficial effect of n-3 PUFA in inflammatory diseases, specifically asthma. Marine-based n-3 PUFA have therefore been proposed as a possible complementary/alternative therapy for asthma. The proposed anti-inflammatory effects of n-3 fatty acids may be linked to a change in cell membrane composition. This altered membrane composition following n-3 fatty acid supplementation (primarily EPA and DHA) can modify lipid mediator generation via the production of eicosanoids with a reduced inflammatory potential/impact. A recently identified group of lipid mediators derived from EPA including E-series resolvins are proposed to be important in the resolution of inflammation. Reduced inflammation attenuates the severity of asthma including symptoms (dyspnoea) and exerts a bronchodilatory effect. There have been no major health side effects reported with the dietary supplementation of n-3 fatty acids or their mediators; consequently supplementing with n-3 fatty acids is an attractive non-pharmacological intervention which may benefit asthma.

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Section: Asthma Pathophysiologymentioning

confidence: 99%

n-3 Fatty acids and asthma

2016

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“…Several studies have also addressed the issue of the role of NO • in airway inflammation in humans. As mentioned above, an increase in NO • , measured, either through its endproducts, nitrite and nitrate, or as FE NO , has been shown to correlate with the degree of airway inflammation (Jatakanon et al, 1998, Silkoff et al, 2000, Sittipunt et al, 2001, Fitzpatrick et al, 2009, Sandrini et al, 2010. However, whether NO • directly affects inflammation or is generated in response to inflammation to attenuate the reaction has not been clearly elucidated.…”

Section: Discussionmentioning

confidence: 99%

Divergent effects of Nitric oxide on airway epithelial cell activation

et al. 2010

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“…13 Além disso, a inflamação das vias aéreas está presente independentemente da presença ou ausência de sintomas, do fenótipo da doença ou de ser uma asma ativa ou em remissão, 10,[14][15][16] contrastando com a obstrução brônquica que é reversível espontaneamente ou após tratamento.…”

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“…11,[16][17][18][19][20][21][22] Um dos métodos que permite avaliar a inflamação das vias aéreas é a biópsia brônquica, contudo, este exame é caro e invasivo, não podendo ser repetido rotineiramente. 16,23 Outro método é a expetoração induzida, no entanto muitas crianças não conseguem expelir as secreções e a obtenção dos resultados é demorada. 16 Contrariamente a estes dois métodos, a medição do FENO é simples, não invasiva e obtêm-se os resultados rapidamente.…”

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“…16,23 Outro método é a expetoração induzida, no entanto muitas crianças não conseguem expelir as secreções e a obtenção dos resultados é demorada. 16 Contrariamente a estes dois métodos, a medição do FENO é simples, não invasiva e obtêm-se os resultados rapidamente. 24 Vários estudos revelaram uma correlação positiva entre o FENO e biópsia brônquica 15,25 e a análise de expetoração.…”

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Fração Exalada de Óxido Nítrico no Controlo e Abordagem Terapêutica da Asma

et al. 2014

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(1) = 8,71; OR = 2,33; p = 0,003) sobre a probabilidade de mudar de nível de controlo da asma. Por cada nível de fração exalada de óxido nítrico incrementado o odds de passar a não controlada é 2,33 vezes superior. Discussão: A probabilidade de uma criança asmática mudar o seu nível de controlo da asma, de 'controlada' para 'parcialmente controlada/não controlada', tendo em consideração uma alteração no seu nível da fração exalada de óxido nítrico, aumenta 133%. Palavras-chave: Criança; Asma; Expiração; Óxido Nítrico; Portugal. AbSTRACTIntroduction: Asthma is a chronic respiratory disease characterized by hyper-responsiveness and bronchial inflammation. The bronchial inflammation in these patients can be monitored by measuring the fractional exhaled nitric oxide. This study aims to determine fractional exhaled nitric oxide association with peak expiratory flow and with asthma control inferred by the Global Initiative for Asthma. Material and Methods:Observational, analytical and cross-sectional study of children with asthma, 6-12 years-old, followed in the Outpatient Respiratory Pathology of Braga Hospital. Sociodemographic and clinical information were collected through a questionnaire. fractional exhaled nitric oxide and peak expiratory flow were determined by portable analyzer Niox Mino ® and flow meter, respectively. Results: The sample is constituted by 101 asthmatic children, 63 (62.4%) of males and 38 (37.6%) females. The mean age of participants in the sample is 9.18 (1.99) years. The logistic regression performed with the cutoff value obtained by ROC curve, revealed that fractional exhaled nitric oxide (b FENO classes = 0.85; χ 2 Wald (1) = 8.71; OR = 2.33; p = 0.003) has a statistical significant effect on the probability of changing level of asthma control. The odds ratio of going from "controlled" to "partly controlled/uncontrolled" is 2.33 per each level of fractional exhaled nitric oxide. Discussion: The probability of an asthmatic children change their level of asthma control, from 'controlled' to 'partly controlled/uncontrolled', taking into account a change in their fractional exhaled nitric oxide level, increases 133%.

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Fractional exhaled nitric oxide in asthma: an update

Abstract: ABSTRACT

Cited by 70 publications

References 171 publications

n-3 Fatty acids and asthma

n-3 Fatty acids and asthma

Divergent effects of Nitric oxide on airway epithelial cell activation

Fração Exalada de Óxido Nítrico no Controlo e Abordagem Terapêutica da Asma

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