This paper focuses on computing the frequency response and transfer functions for large self-similar networks under different circumstances. Modeling large scale systems is difficult due, typically, to the dimension of the problem, and self-similarity is the characteristic we exploit to make the problem more tractable. For each circumstance, we propose algorithms to obtain both transfer functions and frequency response, and we show that finite networks' dynamics are integer order, while infinite networks are fractional order or irrational. Based on that result, we also show that the effect of varying a network's operating condition to its dynamics can always be isolated, which is then expressed as a multiplicative disturbance acting upon a nominal plant. In addition, we analyze the non-integer-order nature residing in infinite dimensional systems in the context of selfsimilar networks. Finally, leveraging the main result of this paper, we also illustrate its capability of approximating some irrational expressions by using rational functions.