Low-level laser therapy (LLLT) is now widely used in dermatology due to the relatively low risk of adverse events. LLLT can modulate mito chondria levels and affect various cell types, such as keratinocytes, lymphocytes, and fibroblasts, leading to its use in various treatments, such as pain reduction, tissue regeneration, and for conditions like inflammatory acne. This study explores the mechanism of action of LLLT and reviews its possible roles as a potential treatment option for common immune-mediated skin diseases, such as alopecia areata, psoriasis, and atopic dermatitis.