Fractional photodamage triggered by chaotic attractors in human lung epithelial cancer cells

Martines-Arano, Hilario; Palacios-Barreto, Samara; Castillo-Cruz, Juan; Meda-Campaña, J. A.; Garcı́a-Pérez, Blanca Estela; Torres-Torres, C.

doi:10.1016/j.ijthermalsci.2022.107734

Cited by 12 publications

(10 citation statements)

References 51 publications

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“…In our studies, the temperature of the sample was slowly raised using a heating element, and the effect of terahertz radiation on the temperature change of the sample was not observed. The complex, inhomogeneous structure of adipose tissue, consisting of cells, septa, and capillaries with different thermal properties, can lead to inhomogeneous heat propagation during laser heating [ 91 ]. However, in our case, with slow heating, the propagation of heat in the adipose tissue could be considered homogeneous.…”

Section: Discussionmentioning

confidence: 99%

Measurement and Modeling of the Optical Properties of Adipose Tissue in the Terahertz Range: Aspects of Disease Diagnosis

et al. 2022

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In this paper, the measurement and modeling of optical properties in the terahertz (THz) range of adipose tissue and its components with temperature changes were performed. Spectral measurements were made in the frequency range 0.25–1 THz. The structural models of main triglycerides of fatty acids are constructed using the B3LYP/6-31G(d) method and the Gaussian03, Revision B.03 program. The optical density (OD) of adipose tissue samples decreases as temperature increases, which can be associated mostly with the dehydration of the sample. Some inclusion of THz wave scattering suppression into the OD decrease can also be expected due to refractive index matching provided by free fatty acids released from adipocytes at thermally induced cell lipolysis. It was shown that the difference between the THz absorption spectra of water and fat makes it possible to estimate the water content in adipose tissue. The proposed model was verified on the basis of molecular modeling and a comparison with experimental data for terahertz spectra of adipose tissue during its heating. Knowing the exact percentage of free and bound water in adipose tissue can help diagnose and monitor diseases, such as diabetes, obesity, and cancer.

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Section: Discussionmentioning

confidence: 99%

Measurement and Modeling of the Optical Properties of Adipose Tissue in the Terahertz Range: Aspects of Disease Diagnosis

et al. 2022

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“…The low cross-section attenuates the signal-to-noise ratio, leading to an increase in measurement time. An extended measurement time not only causes serious damage to the cells but also makes it difficult to measure a large number of cells [ 180 ]. Another limitation of Raman scattering is the difficulty of measuring subtle changes in the proteins and minerals.…”

Section: Latest Technological Advances In Monitoring Stem Cell Status...mentioning

confidence: 99%

“…Although optical spectroscopy is an attractive tool for monitoring stem cell differentiation, it may cause photodamage of cells [ 180 ]. To avoid the photodamage of cells, it is necessary to extend the range of the light source or optimize the procedure to reduce the measurement time.…”

Section: Latest Technological Advances In Monitoring Stem Cell Status...mentioning

confidence: 99%

Recent Advances in Monitoring Stem Cell Status and Differentiation Using Nano-Biosensing Technologies

et al. 2022

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In regenerative medicine, cell therapies using various stem cells have received attention as an alternative to overcome the limitations of existing therapeutic methods. Clinical applications of stem cells require the identification of characteristics at the single-cell level and continuous monitoring during expansion and differentiation. In this review, we recapitulate the application of various stem cells used in regenerative medicine and the latest technological advances in monitoring the differentiation process of stem cells. Single-cell RNA sequencing capable of profiling the expression of many genes at the single-cell level provides a new opportunity to analyze stem cell heterogeneity and to specify molecular markers related to the branching of differentiation lineages. However, this method is destructive and distorted. In addition, the differentiation process of a particular cell cannot be continuously tracked. Therefore, several spectroscopic methods have been developed to overcome these limitations. In particular, the application of Raman spectroscopy to measure the intrinsic vibration spectrum of molecules has been proposed as a powerful method that enables continuous monitoring of biochemical changes in the process of the differentiation of stem cells. This review provides a comprehensive overview of current analytical methods employed for stem cell engineering and future perspectives of nano-biosensing technologies as a platform for the in situ monitoring of stem cell status and differentiation.

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“…The field of fractional calculus explores the concepts of integration and derivatives for non-integer orders. Fractional differential equations (FDEs) can describe many important phenomena, and thus they have applications in different fields of science; see, for example, [1][2][3]. Their solutions become a great necessity.…”

Section: Introductionmentioning

confidence: 99%

A computational strategy for nonlinear time-fractional generalized Kawahara equation using new eighth-kind Chebyshev operational matrices

Ahmed,

Hafez,

Abd-Elhameed

2024

Phys. Scr.

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This paper uses a new method to numerically solve the nonlinear time-fractional generalized Kawahara equations (NTFGKE) with uniform initial boundary conditions (IBCs). A class of modified shifted eighth-kind Chebyshev polynomials (MSEKCPs) is defined to satisfy the given IBCs. The proposed method is based on using operational matrices (OMs) for the ordinary derivatives (ODs) and fractional derivatives (FDs) of MSEKCPs. These OMs are employed together with the spectral collocation method (SCM). Our presented algorithm enables the extraction of efficient and accurate numerical solutions. The convergence of the suggested method and the error analysis have been developed. Three numerical examples are presented to demonstrate the applicability and accuracy of our algorithm. Some comparisons of the presented numerical results with other existing ones are offered to validate the efficiency and superiority of our approach. Tables and graphs demonstrate that the proposed approach produces approximate solutions with high accuracy.

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Fractional photodamage triggered by chaotic attractors in human lung epithelial cancer cells

Cited by 12 publications

References 51 publications

Measurement and Modeling of the Optical Properties of Adipose Tissue in the Terahertz Range: Aspects of Disease Diagnosis

Measurement and Modeling of the Optical Properties of Adipose Tissue in the Terahertz Range: Aspects of Disease Diagnosis

Recent Advances in Monitoring Stem Cell Status and Differentiation Using Nano-Biosensing Technologies

A computational strategy for nonlinear time-fractional generalized Kawahara equation using new eighth-kind Chebyshev operational matrices

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