We study epidemic Susceptible-Infected-Susceptible models in the fractional setting. The novelty is to consider models in which the susceptible and infected populations evolve according to different fractional orders. We study a model based on Caputo derivative, for which we establish existence results of the solutions. Also, we investigate a model based on Caputo-Fabrizio operator, for which we provide existence of solutions and a study of the equilibria. Numerical simulations for both models and a direct numerical comparison are also provided.