Fractionated 5-aminolaevulinic acid-photodynamic therapy vs. surgical excision in the treatment of nodular basal cell carcinoma: results of a randomized controlled trial

Mosterd, Klara; Thissen, M. R. T. M.; Nelemans, Patty J.; Kelleners‐Smeets, Nicole W.J.; Janssen, R.L.L.T.; Broekhof, K.G.M.E.; Neumann, H. A. M.; Steijlen, P.M.; Kuijpers, Daniëlle

doi:10.1111/j.1365-2133.2008.08787.x

Cited by 99 publications

(94 citation statements)

References 32 publications

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“…Also recurrence-free survival was lower with greater tumour thickness [24]. Furthermore, previous research showed that invasive SCC as well as nodular BCC have low overall success rates after PDT [19,25]. These findings suggest that increased epidermal thickness might play a significant role in BD too.…”

Section: Discussionmentioning

confidence: 58%

Photodynamic Therapy in Bowen's Disease: Influence of Histological Features and Clinical Characteristics on Its Success

et al. 2014

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Background: In Bowen's disease (BD) there is no consensus on optimal treatment. Photodynamic therapy (PDT) is an effective non-invasive treatment modality for BD with excellent cosmetic results. Objective: This retrospective study examines whether clinical and histological features of BD impact PDT response. Methods: Patients with previously untreated BD from 2002 until 2007 were identified at the Maastricht University Medical Centre. Patients treated with PDT were included. All histological slides were re-examined. Results: During the study period 98 tumours were treated with PDT. In univariate analysis severe atypia and higher age were associated with decreased probability of clinical clearance. Higher age was also associated with an increased risk of recurrence. In multivariate analysis severe atypia remained the only independent risk factor for therapy failure. Conclusion: In patients with BD, severe atypia and higher age are associated with an increased risk of treatment failure after PDT.

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Section: Discussionmentioning

confidence: 58%

Photodynamic Therapy in Bowen's Disease: Influence of Histological Features and Clinical Characteristics on Its Success

et al. 2014

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“…The 5-aminolevulinic acid-(ALA-) PDT is significantly inferior to surgery for treatment of nodular BCC (3-year clearance rates of 70% and 98%, respectively), 61 although it may still play a role in treating superficial BCC. Studies comparing MAL-PDT with ALA-PDT are needed to further refine treatment protocols.…”

Section: 60mentioning

confidence: 99%

Non-melanoma Skin Cancer in Canada Chapter 4: Management of Basal Cell Carcinoma

et al. 2015

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Background: Basal cell carcinoma (BCC) is the most common malignancy. Growth of BCCs leads to local destruction of neighbouring healthy skin and underlying tissue and can result in significant functional and cosmetic morbidity. Objective: To provide guidance to Canadian health care practitioners regarding management of BCCs. Methods: Literature searches and development of graded recommendations were carried out as discussed in the accompanying Introduction. Results: Although BCCs rarely metastasize, they can be aggressive and disfiguring. This chapter describes the natural history and prognosis of BCCs. Risk stratification is based on clinical features, including the site and size of the tumour, its histologic subtype (nodular vs sclerosing), and its history of recurrence. Conclusions: Various options should be considered for BCC treatment, including cryosurgery, curettage, and topical or photodynamic approaches, as well as fixed-margin surgery and Mohs micrographic surgery. Stratification of recurrence risk for individual BCCs determines the most appropriate therapeutic course. RésuméContexte : Le carcinome basocellulaire (CBC) est le cancer le plus répandu. La croissance d'un CBC mène à la destruction locale de la peau saine environnante et des tissus sous-jacents et peut causer une morbidité fonctionnelle et cosmétique importante. Objectif : Fournir des conseils aux professionnels canadiens de la santé au sujet de la gestion des CBC. Méthode : Nous avons procédé à une étude documentaire et à l'élaboration de catégories de recommandations, comme on peut le lire dans l'introduction connexe. Résultats : Le CBC forme rarement des métastases, mais il peut être agressif et défigurant. Ce chapitre décrit l'évolution et le pronostic du CBC. La stratification du risque est fondée sur les caractéristiques cliniques, y compris l'emplacement et la taille de la tumeur, et son sous-type histologique (nodulaire ou sclérosant), et sur les antécédents de récurrence. Conclusion : Diverses options devraient être envisagées dans le traitement du CBC, y compris la cryochirurgie, le curetage et les approches topiques ou photodynamiques, ainsi que la chirurgie à marge déterminée et la chirurgie micrographique de Mohs. La stratification du risque de récurrence de chaque CBC individuel détermine le traitement thérapeutique le plus approprié.

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“…Fractionated ALA-PDT is comparable to surgery in clearing nBCC. However, failure rates during long-term follow-up vary between 20 and 31 % at 2-5 years depending on fractionated dosing protocol and debulking pretreatment (de Haas et al 2007(de Haas et al , 2008Mosterd et al 2008 ;Roozeboom et al 2013 ).…”

Section: Nodular Basal Cell Carcinomamentioning

confidence: 98%

Photodynamic Therapy for Malignant Skin Lesions

Kaminska

Pei

Tsoukas

2015

European Handbook of Dermatological Treatments

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Fractionated 5-aminolaevulinic acid-photodynamic therapy vs. surgical excision in the treatment of nodular basal cell carcinoma: results of a randomized controlled trial

Abstract: SE proved to be significantly more effective than treatment with fractionated illumination ALA-PDT. Therefore, in the treatment of primary nBCC, SE is preferred over PDT following this treatment regimen.

Cited by 99 publications

References 32 publications

Photodynamic Therapy in Bowen's Disease: Influence of Histological Features and Clinical Characteristics on Its Success

Photodynamic Therapy in Bowen's Disease: Influence of Histological Features and Clinical Characteristics on Its Success

Non-melanoma Skin Cancer in Canada Chapter 4: Management of Basal Cell Carcinoma

Photodynamic Therapy for Malignant Skin Lesions

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