Fractionated aliphatic alcohols as synthetic precursors of ultra long‐chain monoacylglycerols for cosmetic applications

Pérez, Bianca; Hansen, Bjørn S.; Bulsara, Pallav A.; Rawlings, A. V.; Clarke, Martyn J.; Guo, Zheng

doi:10.1111/ics.12404

Cited by 19 publications

(2 citation statements)

References 38 publications

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“…Fatp4 −/− epidermis showed dramatically decreased proportions of all MAG species carrying a saturated acyl chain ranging from 22 to 30 carbons. In an in vitro study, a mixture of MAG species containing a saturated acyl chain ranging from 22 to 26 carbons displayed better occlusive properties than petroleum jelly, which contains a mixture of hydrocarbons, suggesting a role for MAG in the skin barrier 54 . It is unlikely that the epidermal MAG was mainly produced from enzymatic or non-enzymatic lipolysis of triacylglycerols and diacylglycerols.…”

Section: Discussionmentioning

confidence: 95%

Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols

Lin

Hsu

Crumrine

et al. 2019

Sci Rep

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Fatty acid transport protein 4 (FATP4) is an acyl-CoA synthetase that is required for normal permeability barrier in mammalian skin. FATP4 (SLC27A4) mutations cause ichthyosis prematurity syndrome, a nonlethal disorder. In contrast, Fatp4−/− mice die neonatally from a defective barrier. Here we used electron microscopy and lipidomics to characterize defects in Fatp4−/− mice. Mutants showed lamellar body, corneocyte lipid envelope, and cornified envelope abnormalities. Lipidomics identified two lipids previously speculated to be present in mouse epidermis, sphingosine β-hydroxyceramide and monoacylglycerol; mutants displayed decreased proportions of these and the two ceramide classes that carry ultralong-chain, amide-linked fatty acids (FAs) thought to be critical for barrier function, unbound ω-O-acylceramide and bound ω-hydroxyceramide, the latter constituting the major component of the corneocyte lipid envelope. Other abnormalities included elevated amounts of sphingosine α-hydroxyceramide, phytosphingosine non-hydroxyceramide, and 1-O-acylceramide. Acyl chain length alterations in ceramides also suggested roles for FATP4 in esterifying saturated non-hydroxy and β-hydroxy FAs with at least 25 carbons and saturated or unsaturated ω-hydroxy FAs with at least 30 carbons to CoA. Our lipidomic analysis is the most thorough such study of the Fatp4−/− mouse skin barrier to date, providing information about how FATP4 can contribute to barrier function by regulating fatty acyl moieties in various barrier lipids.

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Section: Discussionmentioning

confidence: 95%

Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols

Lin

Hsu

Crumrine

et al. 2019

Sci Rep

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“…Although earlier studies using DSC were focused on studying the mechanical or biophysical properties of skin and its basic composition [11][12][13][14], the technique remains popular and continues to be employed in studies of cosmetic ingredients [15][16][17][18] and liposome-assisted drug delivery [19][20][21][22][23][24], where DSC serves as a primary tool in characterizing the matrix state, with polymorphism and drug incorporation in lipid dispersions [3].…”

Section: Differential Scanning Calorimetrymentioning

confidence: 99%

Review of Modern Techniques for the Assessment of Skin Hydration

Qassem

Kyriacou

2019

Cosmetics

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Skin hydration is a complex process that influences the physical and mechanical properties of skin. Various technologies have emerged over the years to assess this parameter, with the current standard being electrical probe-based instruments. Nevertheless, their inability to provide detailed information has prompted the use of sophisticated spectroscopic and imaging methodologies, which are capable of in-depth skin analysis that includes structural and composition details. Modern imaging and spectroscopic techniques have transformed skin research in the dermatological and cosmetics disciplines, and are now commonly employed in conjunction with traditional methods for comprehensive assessment of both healthy and pathological skin. This article reviews current techniques employed in measuring skin hydration, and gives an account on their principle of operation and applications in skin-related research.

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Water-mediated catalyst-free synthesis of lysine-based ampholytic amphiphiles for multipurpose applications: Characterization and pH-responsive emulsifying properties

Cheng

Anankanbil

Pérez

et al. 2019

Journal of Colloid and Interface Science

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Fractionated aliphatic alcohols as synthetic precursors of ultra long‐chain monoacylglycerols for cosmetic applications

Abstract: Performacol 425 can be a potential source of fatty alcohols to synthesize monoacylglycerols that can improve the occlusive behaviour of phospholipid-structured emulsions.

Cited by 19 publications

References 38 publications

Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols

Fatty acid transport protein 4 is required for incorporation of saturated ultralong-chain fatty acids into epidermal ceramides and monoacylglycerols

Review of Modern Techniques for the Assessment of Skin Hydration

Water-mediated catalyst-free synthesis of lysine-based ampholytic amphiphiles for multipurpose applications: Characterization and pH-responsive emulsifying properties

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