Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii

Zhou, Xianrong; Shang, Jin; Qin, Mingyi; Wang, Jianhua; Jiang, Bo; Yang, Hui; Yan, Zhang

doi:10.3390/molecules24183402

Cited by 12 publications

(8 citation statements)

References 32 publications

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“…However, our study did not confirm the presence of taxoleic acid (18:2Δ5,9), a typical FA for lipids of Taxus baccata seeds ( Table S1 ) [ 20 , 21 , 22 ]. Substantial differences between the FAs profile of pericarp and seeds of fruits confirmed a previous study on Garcinia fruits [ 46 ]…”

Section: Resultssupporting

confidence: 87%

“…However, our study did not confirm the presence of taxoleic acid (18:2∆5,9), a typical FA for lipids of Taxus baccata seeds (Table S1) [20][21][22]. Substantial differences between the FAs profile of pericarp and seeds of fruits confirmed a previous study on Garcinia fruits [46] There are several factors that can affect FAs composition including plant origin, environmental conditions and temperature, throughout the time between flowering and ripening [47]. For example, low temperature promotes the synthesis of PUFAs in plants, especially the LC-PUFA ones [29].…”

Section: Fatty Acid Compositioncontrasting

confidence: 84%

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Red Arils of Taxus baccata L.—A New Source of Valuable Fatty Acids and Nutrients

Tabaszewska¹,

Rutkowska

Skoczylas³

et al. 2021

Molecules

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The aim of this study, focused on the nutritional value of wild berries, was to determine the contents of macronutrients, profiles of fatty (FAs) and amino acids (AAs), and the contents of selected elements in red arils (RA) of Taxus baccata L., grown in diverse locations in Poland. Protein (1.79–3.80 g/100 g) and carbohydrate (18.43–19.30 g/100 g) contents of RAs were higher than in many cultivated berries. RAs proved to be a source of lipids (1.39–3.55 g/100 g). Ten out of 18 AAs detected in RAs, mostly branched-chain AAs, were essential AAs (EAAs). The EAAs/total AAs ratio approximating were found in animal foods. Lipids of RA contained seven PUFAs, including those from n-3 family (19.20–28.20 g/100 g FA). Polymethylene-interrupted FAs (PMI-FAs), pinolenic 18:3Δ5,9,12; sciadonic 20:3Δ5,11,14, and juniperonic 20:4Δ5,11,14,17, known as unique for seeds of gymnosperms, were found in RAs. RAs may represent a novel dietary source of valuable n-3 PUFAs and the unique PMI-FAs. The established composition of RAs suggests it to become a new source of functional foods, dietary supplements, and valuable ingredients. Because of the tendency to accumulate toxic metals, RAs may be regarded as a valuable indicator of environmental contamination. Thus, the levels of toxic trace elements (Al, Ni, Cd) have to be determined before collecting fruits from natural habitats.

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Section: Resultssupporting

confidence: 87%

Section: Fatty Acid Compositioncontrasting

confidence: 84%

Red Arils of Taxus baccata L.—A New Source of Valuable Fatty Acids and Nutrients

Tabaszewska¹,

Rutkowska

Skoczylas³

et al. 2021

Molecules

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“…Thus, like the omega-3 FA EPA, sciadonic acid both inhibits AA metabolism by COX and acts as an alternative COX substrate. An oil rich in sciadonic acid was reported to inhibit 5-lipoxygenase activity in a model assay system and topical application of the oil reduced ear inflammation (oedema) induced by xylene in mice [56].…”

Section: Effects Of Nmifas From Pine Nut Oil Other Than Pinolenic Acidmentioning

confidence: 99%

A review of the functional effects of pine nut oil, pinolenic acid and its derivative eicosatrienoic acid and their potential health benefits

Baker

Miles

Calder

2021

Progress in Lipid Research

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“…Our group and others have shown SA to exert anti-inflammatory actions by reducing levels of ARA and downstream mediators in in vitro and animal models [ 1 – 8 ]. Topical anti-inflammatory properties using lipidic seed extracts rich in SA have also been demonstrated [ 1 , 6 , 9 – 11 ]. Delta-5® oil (Delta-5) refers to the oil sold by SciaEssentials®, LLC with 20–25% SA.…”

Section: Introductionmentioning

confidence: 99%

Delta-5® oil, containing the anti-inflammatory fatty acid sciadonic acid, improves skin barrier function in a skin irritation model in healthy female subjects

Berger¹

2022

Lipids Health Dis

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Background Sciadonic acid (SA) is an anti-inflammatory fatty acid displacing arachidonic acid (ARA) from specific phospholipid pools, thus modulating downstream pro-inflammatory lipid mediators. Its novel anti-inflammatory actions have been studied in vitro, in pre-clinical models, and stemming from testimonials, after topical- and oral application. It has not been tested in a formal clinical study for topical benefits previously. Skin barrier layer was our focus as it has a critically important role in maintaining skin moisture balance. Methods Herein, forearm skin was left undamaged; or barrier layer was chemically-damaged with 2% sodium lauryl sulfate (SLS) for 24 h. SLS-damaged skin was left untreated or treated with Delta-5® oil containing 24% SA twice daily for 27 days. Barrier function was assessed by open chamber transepidermal water loss (TEWL) and skin surface impedance on days 0 (clear skin), -1 (1-day post-SLS), -2 (2-days post-SLS, 1-day post-Delta-5), -3, -7, and − 28. Results Relative to day 1, Delta-5 oil statistically significantly decreased TEWL vs. untreated damaged sites, on days 3 (125% more reduced), -7 (74% more reduced), and − 28 (69% more reduced). Decreases in TEWL following chemical damage indicates improved skin barrier repair and healing. Similar patterns were quantified for skin impedance. There was also reduced redness observed on days 3 and − 7 with Delta-5 oil vs. untreated SLS-damaged skin. Conclusions Delta-5 oil thus has anti-inflammatory potential in human skin, under controlled clinical conditions, to accelerate irritant-induced healing, and improve skin barrier function. Improvement in barrier function would benefit dermatitis, acne, eczema, and skin scarring. In normal skin, Delta-5 oil has potential to promote healthy, moisturized skin; and improve skin structure, elasticity, and firmness.

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Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii

Cited by 12 publications

References 32 publications

Red Arils of Taxus baccata L.—A New Source of Valuable Fatty Acids and Nutrients

Red Arils of Taxus baccata L.—A New Source of Valuable Fatty Acids and Nutrients

A review of the functional effects of pine nut oil, pinolenic acid and its derivative eicosatrienoic acid and their potential health benefits

Delta-5® oil, containing the anti-inflammatory fatty acid sciadonic acid, improves skin barrier function in a skin irritation model in healthy female subjects

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