Fractionated stereotactic radiotherapy in the treatment of exclusive cavernous sinus meningioma: functional outcome, local control, and tolerance

Brell, Marta; Villà, Salvador; Teixidor, Pilar; Lucas, Anna; Ferrán, E.; Marin, S.; Acebes, J.J.

doi:10.1016/j.surneu.2005.06.027

Cited by 81 publications

(74 citation statements)

References 32 publications

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“…3). These results are reasonably similar to those published for other FSR (Brell et al, 93% at 4 years [1] and radiosurgery studies (Roche et al, 92.8% at 5 years; [7], Pollock and Stafford, 98% at 1 year and 85% at 3 years [6], Mettelus et al, 94.4% at 5 and 10 years [8]); see Table 2.…”

Section: Tumor Controlsupporting

confidence: 90%

“…Symptoms of this kind were not reported in either our study or that completed by Brell et al (1). It is even possible to irradiate the nerves directly while ensuring appropriate tumor control and functional control (5).…”

Section: Discussionmentioning

confidence: 65%

“…FSR is an attractive alternative because it facilitates both appropriate tumor control (1,3,8,12,13) and a significant reduction in functional symptoms. In our study, the best results were achieved for impaired visual acuity (67% improvement).…”

Section: Discussionmentioning

confidence: 99%

“…An overview is provided in Table 1. The mean patient age during treatment was 56 years (range, 30-73); 84% of the patients treated were female, which is typical for this type of pathology (1,4,(7)(8)(9). Twenty-six percent of the patients were initially treated with what was assumed to be complete surgery.…”

Section: Patientsmentioning

confidence: 99%

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Fractionated Stereotactic Radiotherapy Treatment of Cavernous Sinus Meningiomas: A Study of 100 Cases

Litré

Colin

Noudel

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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Purpose: We discuss our experiences with fractionated stereotactic radiotherapy (FSR) in the treatment of cavernous sinus meningiomas. Methods and Materials: From 1995 to 2006, we monitored 100 patients diagnosed with cavernous sinus meningiomas; 84 female and 16 male patients were included. The mean patient age was 56 years. The most common symptoms were a reduction in visual acuity (57%), diplopia (50%), exophthalmy (30%), and trigeminal neuralgia (34%). Surgery was initially performed on 26 patients. All patients were treated with FSR. A total of 45 Gy was administered to the lesion, with 5 fractions of 1.8 Gy completed each week. Patient treatment was performed using a Varian Clinac linear accelerator used for cranial treatments and a micro-multileaf collimator. Results: No side effects were reported. Mean follow-up period was 33 months, with 20% of patients undergoing follow-up evaluation of more than 4 years later. The tumor control rate at 3 years was 94%. Three patients required microsurgical intervention because FSR proved ineffective. In terms of functional symptoms, an 81% improvement was observed in patients suffering from exophthalmy, with 46% of these patients being restored to full health. A 52% improvement was observed in diplopia, together with a 67% improvement in visual acuity and a 50% improvement in type V neuropathy. Conclusions: FSR facilitates tumor control, either as an initial treatment option or in combination with microsurgery. In addition to being a safe procedure with few side effects, FSR offers the significant benefit of superior functional outcomes. Ó 2009 Elsevier Inc.

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Section: Tumor Controlsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

See 2 more Smart Citations

Fractionated Stereotactic Radiotherapy Treatment of Cavernous Sinus Meningiomas: A Study of 100 Cases

Litré

Colin

Noudel

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…4,5,10,23,35,[38][39][40][44][45][46] The incidence of visual deterioration following fractionated stereotactic radiotherapy in one study was 3%.…”

mentioning

confidence: 99%

Technical nuances in the management of tuberculum sellae and diaphragma sellae meningiomas

Nanda

Ambekar²,

Javalkar³

et al. 2013

FOC

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Object Tuberculum sellae meningiomas (TSMs) and diaphragma sellae meningiomas (DSMs) are challenging lesions to treat due to their proximity to neurovascular structures. Methods The authors reviewed the medical records of patients who underwent surgical excision of TSMs and DSMs from 1990 to 2013. They also describe the technical strategies used to minimize injury to the optic apparatus, vascular structures, and pituitary stalk. Results Twenty-four patients with TSM and 6 patients with DSM were included in the study. Seventy percent of the tumors were large (≥ 5 cm). The pterional approach was employed in most cases. Optic canal involvement was observed in 4 patients. Twenty-one patients (70%) had visual dysfunction before surgery. At follow-up (median 18 months), visual improvement was noted in 10 (47.6%) of 21 patients. Gross-total excision was achieved in 22 patients (91.6%) with TSM and 5 (83.3%) with DSM. At last follow-up, 28 patients (93.3%) had a Glasgow Outcome Scale score of 5. There were no deaths in this series. Conclusions Tuberculum and diaphragma sellae meningiomas present a unique subset of tumors due to their location. They can be safely excised with minimal morbidity and mortality using microsurgical techniques. Attention to technical details during surgery leads to greater respectability and superior visual outcome.

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Radiosurgery in the Treatment of Primary Brain Neoplasms

Iranmehr,

Jafari,

Paeinmahali

et al. 2023

Interdisciplinary Cancer Research

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Fractionated stereotactic radiotherapy in the treatment of exclusive cavernous sinus meningioma: functional outcome, local control, and tolerance

Cited by 81 publications

References 32 publications

Fractionated Stereotactic Radiotherapy Treatment of Cavernous Sinus Meningiomas: A Study of 100 Cases

Fractionated Stereotactic Radiotherapy Treatment of Cavernous Sinus Meningiomas: A Study of 100 Cases

Technical nuances in the management of tuberculum sellae and diaphragma sellae meningiomas

Radiosurgery in the Treatment of Primary Brain Neoplasms

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