Fractionated stereotactic radiotherapy with linear accelerator for uveal melanoma — Preliminary vienna results

Abstract

Optical fixation of the eye allows high precision stereotactic radiotherapy with small safety margins. Fractionated stereotactic radiotherapy and 70 Gy total dose delivered in 5 fractions seems to be appropriate for local tumor control in uveal melanoma. Further long-term studies with extended number of patients will be necessary to conclude on the use of linac-based fractionated stereotactic radiotherapy for uveal melanoma.

Local Tumor Control, Visual Acuity, and Survival After Hypofractionated Stereotactic Photon Radiotherapy of Choroidal Melanoma in 212 Patients Treated Between 1997 and 2007

“…In the past decade, linear accelerator (LINAC) based stereotactic radiotherapy (SRT) of uveal melanoma has been investigated for its potential as an alternative option (25)(26)(27)(28)(29)(30)(31)(32)(33). A reliable eye fixation technique with online control to ensure successful irradiation of the tumor volume has been developed and investigated (26,34).…”

Teletherapy: Advanced Techniques

“…However, with fractionated stereotactic radiation therapy, the radiation is delivered over multiple treatments [43,[46][47][48][49][50][51].…”

Radiotherapy in ophthalmology

“…The treatments used most widely at the present time are 106 Ru/ 106 Rh applicators, 125 I applicators and proton beam radiotherapy. Other methods and treatment modalities used by some groups include palladium ( 103 Pd) applicators [27] loaded with a radioisotope that emits gamma radiation with a lower energy than that emitted by 125 I; gamma knife, which delivers circumscribed irradiation, although with wide diffusion around the target [47,94]; and linear accelerator, combined with Schipper's device [12] or a conformal stereotactic technique [11,93].…”