“…Thermal field-flow fractionation (ThFFF) is a subtechnique of the field-flow fractionation family that employs a temperature gradient perpendicular to a carrier liquid flowing through an open, ribbon-like channel in order to fractionate analytes according to size, chemical composition and microstructure. − The applied temperature gradient drives analytes from the hot wall toward the cold wall (accumulation wall) of the channel. This temperature-induced migration is termed thermal diffusion and is described by the thermal diffusion coefficient, D T, which (among other factors) is dependent on the chemical nature of the analytes and the solvent. ,,, Thermal diffusion is balanced by normal diffusion which is the migration of analytes away from the accumulation wall toward the center of the channel due to increasing analyte concentration. , Normal diffusion is described by the normal diffusion coefficient, D , and is dependent on the size of the analytes in solution. ,, …”