“…The discovery of the human SOST (Sclerosteosis) gene is a triumph for the study of human genetics. Sclerosteosis and Van Buchem diseases are rare sclerosing bone dysplasias, discovered more than 40 years ago by Hansen et al (1967), and are inherited in an autosomal recessive fashion. Each disease is manifested by a greatly increased amount of bone mass, with Sclerosteosis being the most severe (Beighton, 1976; Beighton et al, 1976a, b, 1977a, b; Balemans et al, 2001; Brunkow et al, 2001).…”