In order to study the influence of cement hydration heat release on the mechanical properties of casing, this paper calculates the wellbore temperature and pressure field based on the mathematical model of steady-state heat conduction of casing-cement ring-formation rock, establishes a mathematical model for the mechanical evaluation of cement hydration heat release and casing interaction, and performs finite element calculation and experimental simulation of the effect of cement hydration heat release on casing loss, and the results show that the results show: Along the axial direction of the wellbore, the maximum stress on the entire cement ring occurs in the lower position of the cement ring, and the maximum deformation on the casing occurs in the middle position. The axial stress variation range of the middle part of the casing is 50MPa, and the strain is 0.12%; The axial stress variation range of the outer ring is 235MPa, and the strain is 0.09%; The circumferential stress of the middle part varies from 500MPa to 0.255%. It is found that the stress and strain in the middle part of cement sheath are large, and yield is prone to occur. Under the action of cement hydration heat release, the long-axis elliptical deformation of (7.15∼31.8) mm occurs in the casing, that is, a large ovality is produced, which weakens the collapse strength of the casing. Two repeated tests showed that under the cement hydration heat release condition at the casing loss position, the temperature change of 60°C caused the increase of axial force of casing column and the increase of annular air pressure, which caused the non-uniform deformation of casing under the composite load of external extrusion and compression axial force.