Fracture of the Distal Radius by Tuberculous Osteomyelitis: A Case Report and Review of Literature

Garcia-Reza, Alejandro; Castro-Menéndez, M.; Domínguez-Prado, Diego Matías; Yañez-Calvo, Javier

doi:10.1142/s2424835522720183

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…[23] In Alejandro study on patients with tuberculous osteomyelitis and DRFs, it was found that to improve the treatment of the fracture, it is necessary to clear the inflammation (abscess) in the bone. [24] The study showed a strong correlation between platelet expression levels and DRFs, which is consistent with previous research findings. Choi [25] conducted a study on spayed female Toy Poodles with radius-ulna fractures.…”

Section: Discussionsupporting

confidence: 92%

Effect of platelet content on occurrence and prognosis of distal radius fracture

Ding,

Zhu,

Zheng

et al. 2023

Medicine

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Fractures of the distal radius are a common fracture with an increasing incidence. However, the underlying factors for distal radius fractures (DRFs) remain unclear. A total of 123 patients with distal radial fractures were recruited. To document clinical and follow-up data, and measure the levels of white blood cells, hemoglobin, platelets, and red blood cells in the bloodstream for qualitative observation of their expression effects within the human body, specifically assessing whether the magnitudes of these indicators are associated with potential factors influencing DRF. Pearson chi-square test and Spearman correlation were used to analyze the relationship between DRF and related parameters. Univariate and multivariate logistic regression and multivariate Cox proportional risk regression were used for further analysis. Pearson chi-square test and Spearman correlation analysis showed a significant correlation between platelet and red blood cell levels and the occurrence of DRFs. Univariate logistic regression analysis demonstrated a significant correlation between platelet count (OR [odds ratio] = 6.286, 95% CI [confidence interval]: 2.862–13.808, P < .001) and red blood cell count (OR = 2.780, 95% CI: 1.322–5.843, P = .007) with DRFs. Increasing levels of both indicators were associated with a higher susceptibility to DRFs. Multivariate logistic regression showed that platelets (OR = 6.344, 95% CI: 2.709–14.855, P < .001) were significantly associated with DRFs. Multivariate Cox regression analysis showed sex (HR [hazard ratio] = 0.596, 95% CI: 0.381–0.931, P = .023) and platelet (HR = 3.721, 95% CI: 2.364–5.855, P < .001) were significantly associated with maintenance time from recovery to recurrence (MTRR) of DRFs. In other words, the platelet content in the body of different genders is different, and the MTRR of DRF is different. Platelets were significantly associated with DRFs. The higher the platelet count, the higher the risk of DRF and the shorter the time of DRF recurrence.

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Section: Discussionsupporting

confidence: 92%

Effect of platelet content on occurrence and prognosis of distal radius fracture

Ding,

Zhu,

Zheng

et al. 2023

Medicine

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“…Two of the five S. epidermidis strains were Methicillin-Resistant Staphylococcus epidermidis. The mNGS mainly identified 11 strains of anaerobes [ 31 ] and 2 strains of MTB [ 32 , 33 ]. However, the overall positive detection rate did not reach statistical significance.…”

Section: Discussionmentioning

confidence: 99%

Composition of pathogenic microorganism in chronic osteomyelitis based on metagenomic sequencing and its application value in etiological diagnosis

Zhang,

Bai,

Liu

et al. 2023

BMC Microbiol

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Background Traditionally, conventional microbiological culture methods have been used to detect pathogenic microorganisms in chronic osteomyelitis. However, these methods have been found to have a low detection rate, complicating the precise guidance of infection treatment. This study employed metagenomic next-generation sequencing (mNGS) to detect these microorganisms in chronic osteomyelitis with three main objectives: 1). Gain a deeper understanding of the composition of pathogenic microorganisms in chronic osteomyelitis. 2). Compare the microbial detection rates between mNGS and the standard culture methods used in laboratories to enhance the effectiveness of the traditional culture methods. 3). Explore the potential of mNGS in etiological diagnosis. Methods Fifty clinically confirmed intraoperative bone tissue samples of chronic osteomyelitis from January 2021 to December 2021 were collected and subjected to mNGS and microbiological testing, respectively. The orthopaedic surgeon combined clinical manifestations and related examinations to determine the causative pathogens. Results The culture method obtained 29 aerobic and parthenogenic anaerobic bacteria, 3 specific anaerobic bacteria, and 1 yeast-like fungus. Thirty-six aerobic and parthenogenic anaerobic bacteria, 11 specific anaerobic bacteria, and 1 yeast-like fungus were obtained by mNGS, and 2 Mycobacterium tuberculosis(MTB) strains were detected. However, there was no significant difference in the overall positive detection rate between mNGS and the culture method (P = 0.07), and the two were not statistically significant in detecting aerobic and partly anaerobic bacteria (P = 0.625). But, mNGS was significantly superior to culture in detecting anaerobic bacteria and Mycobacterium tuberculosis (P<0.05). Conclusions The mNGS method has enhanced our understanding of the distribution of pathogenic microorganisms in chronic osteomyelitis. Traditional culture methods help isolate and cultivate aerobic and facultative anaerobic bacteria, and fungi, and are also utilized for antibacterial drug sensitivity tests. However, mNGS has shown superior capabilities in detecting anaerobic bacteria, MTB, and mixed infection bacteria. This finding offers invaluable guidance for improving laboratory microbial culture and detection conditions. Hence, mNGS should be judiciously used for chronic osteomyelitis, and PCR can be implemented for certain difficult-to-culture microorganisms, such as MTB.

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Fracture of the Distal Radius by Tuberculous Osteomyelitis: A Case Report and Review of Literature

Cited by 2 publications

References 7 publications

Effect of platelet content on occurrence and prognosis of distal radius fracture

Effect of platelet content on occurrence and prognosis of distal radius fracture

Composition of pathogenic microorganism in chronic osteomyelitis based on metagenomic sequencing and its application value in etiological diagnosis

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