The present work aims to investigate the failure size effect on flattened disks containing an eccentric circular hole under mode I loading conditions. For this purpose, uniaxial compression tests are carried out on polymethyl methacrylate (PMMA) samples with holes. Depending on the hole radius and eccentricity, the energy release rate is either an increasing or decreasing function of the crack length, thus affecting the stability of crack propagation. Experimental results are interpreted and discussed through the coupled stress and energy criterion of Finite Fracture Mechanics. The approach lies on the assumption of a finite crack advance and it is implemented through the numerical estimation of the stress field and the Incremental Energy Release Rate functions. Finally, stability and crack speed propagation are discussed under the assumption of Linear Elastic Fracture Mechanics. Theoretical predictions reveal in agreement with experimental results thus demonstrating that the Coupled Criterion effectively captures the failure condition.