2007
DOI: 10.1016/j.bone.2007.04.193
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Fracture repair: Modulation of fracture-callus and mechanical properties by sequential application of IL-6 following PTH 1–34 or PTH 28–48

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Cited by 45 publications
(40 citation statements)
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“…94 In an in vivo fracture healing model, repeated local injections of parathyroid hormone fragments and IL-6 in the first 2 weeks after injury significantly increased fracture callus mechanical strength and accelerated osseous union. 95 However, this treatment reduced the mechanical strength of noninjured bones, which was attributed to a systemic effect of the injected agents. 95 This underscores the need for controlled release systems to provide targeted cytokine delivery to the site of bone injury.…”
mentioning
confidence: 99%
“…94 In an in vivo fracture healing model, repeated local injections of parathyroid hormone fragments and IL-6 in the first 2 weeks after injury significantly increased fracture callus mechanical strength and accelerated osseous union. 95 However, this treatment reduced the mechanical strength of noninjured bones, which was attributed to a systemic effect of the injected agents. 95 This underscores the need for controlled release systems to provide targeted cytokine delivery to the site of bone injury.…”
mentioning
confidence: 99%
“…Injection of growth factors is based on the tremendous effect that these molecules exert to induce upregulation of bone healing [91]. Currently, a variety of molecules including BMP-2, BMP-7, platelet-derived growth factor, fibroblast derived growth factor and PTH have been used for the treatment of nonunions in experimental studies (animal models) [4,7,8,50,67,71,77,95,97,100,114]. The results have shown that the molecules are capable of upregulating the healing process, thus accelerating the fracture consolidation and mechanical properties [50, 71,77,89,95,100,114].…”
Section: Discussionmentioning
confidence: 99%
“…The usefulness of this technique is still under intense study by several investigators using different animal models [4,67,77,95,97,100]. Simple injection of osteoinductive growth factors in subcutaneous tissue has showed that it can promote bone formation [97,100].…”
Section: Injection Of Growth Factors For Enhancement Of Fracture Healingmentioning
confidence: 99%
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