Fracture Risk After Bilateral Oophorectomy in Elderly Women

Melton, L. Joseph; Khosla, Sundeep; Malkasian, George D.; Achenbach, Sara J.; Oberg, Ann L.; Riggs, B. Lawrence

doi:10.1359/jbmr.2003.18.5.900

Cited by 113 publications

(62 citation statements)

References 60 publications

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“…The latter is of particular concern since bilateral oophorectomy is associated with an increased risk of fractures, although the greatest risk appears to be for those with oophorectomy prior to age 45 [24,25]. An increased risk of heart disease and stroke, as well as excess mortality, has been associated with oophorectomy prior to age 45 in the general population, most apparent in those who did not take HRT after oophorectomy [7,19,[26][27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

Non-cancer endpoints in BRCA1/2 carriers after risk-reducing salpingo-oophorectomy

et al. 2011

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Risk-reducing salpingo-oophorectomy (RRSO) significantly reduces the risk of ovarian cancer and breast cancer in pre-menopausal women with BRCA1 and BRCA2 (B1/2) mutations. Despite its clear benefits, little is known about non-cancer endpoints in this population. Medical records were examined in 226 B1/2 mutation carriers, who had previously undergone RRSO with a focus on bone health as well as the frequency of hypertension, hyperlipidemia, coronary artery disease (CAD), myocardial infarction (MI), diabetes, hypothyroidism and depression. From the medical records, DEXA scans, medications and medical conditions were recorded. Of the 226 patient records examined, 16% (36/226) had hypertension, 17% (39/226) hyperlipidemia, 2% (5/226) CAD or MI, 2% (4/226) diabetes, 13% (29/226) hypothyroidism and 14% (31/226) depression. DEXA results were available in 152 women. Of those DEXA scans, 71% (108/152) were abnormal (57% osteopenia and 14% osteoporosis). Among women who underwent RRSO prior to age 50, 71% (62/88) had osteopenia/osteoporosis. Although there was no difference in osteopenia/osteoporosis in women with RRSO prior to age 50 compared to those RRSO > 50, the age at follow up in these two groups differs greatly (mean age 44.7 vs. 60.6), suggesting that both current age and age at RRSO contribute to bone health assessment. In summary, here, we report the prevalence of non-cancer endpoints in a cohort of B1/2 mutation carriers and note a particularly high rate of osteopenia and osteoporosis in B1/2 with breast cancer undergoing RRSO prior to 50. Despite the risk reduction RRSO offers, attention should be paid to non-cancer endpoints, particularly bone health, in this population.

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Section: Discussionmentioning

confidence: 99%

Non-cancer endpoints in BRCA1/2 carriers after risk-reducing salpingo-oophorectomy

et al. 2011

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“…We previously showed that osteoporotic fracture risk was elevated 1.5-fold among 340 women who underwent bilateral oophorectomy following a natural menopause (1). To the extent that the ovaries contribute to postmenopausal estrogen production via extragonadal conversion of ovarian androgens to estrogen (2), oophorectomy might have exacerbated bone loss in these women and increased their risk of fracture.…”

Section: Introductionmentioning

confidence: 99%

Influence of hysterectomy on long-term fracture risk

Melton

Achenbach

Gebhart

et al. 2007

Fertility and Sterility

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Objective-To assess long-term fracture risk following hysterectomy, with or without oophorectomy.Design-Population-based cohort study. Setting-Olmsted County, Minnesota. Patients-9258Olmsted County women who underwent hysterectomy in 1965-2002 compared to an equal number of age-and sex-matched community controls.Interventions-Observational study of the effect of hysterectomy for various indications on subsequent fractures.Main outcome measures-Fractures of any type, and at osteoporotic sites (e.g., hip, spine, and wrist) alone, as assessed by electronic review of inpatient and outpatient diagnoses in the community.Results-Compared to controls, there was a significant increase (hazard ratio [HR], 1.21; 95% CI, 1.13-1.29) in overall fracture risk among the women with hysterectomy, but osteoporotic fracture risk was not elevated (HR, 1.09; 95% CI, 0.98-1.22). Most hysterectomy indications were associated with fractures generally, albeit often not statistically significantly, but only operations for uterine prolapse were associated with osteoporotic fractures (HR, 1.33; 95% CI, 1.01-1.74). Oophorectomy was not an independent predictor of fracture risk (HR, 1.0; 95% CI, 0.98-1.15).Conclusions-Hysterectomy does not appear to pose much long-term risk for fractures, but the association of fractures with surgery for uterine prolapse deserves further attention.

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“…Bones that are affected by osteoporosis can fracture with relatively minor injury that normally would not cause a bone to fracture. The Fracture can be either in the form of cracking or collapsing [2] …”

Section: What Is Osteoporosismentioning

confidence: 99%

“…Currently, we compute the posterior probability P(X|Yes) and P(X|No) by using equation (2).The Bayes Error Rate was compute as in equation (4). Figure( 24) show the Osteoporosis Naïve Bayes classification, for each patent.…”

Section: Fig 23: Form Of the Prior Probabilitymentioning

confidence: 99%

Design Advance Database Supported with some of Data Mining Ensemble for Early Deduction of Osteoporosis

Al-Deen¹,

Fahady²,

Al-jarah³

2015

IJCA

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A computerize Osteoporosis system has been designed, it is based on a database with factors that represent the cause of Osteoporosis, in this database the Visual Basic.net language were used for designing system forms ,as well as TSQL language and SQL Server. Data Mining is considered to be the most important tool used to extract information from data and uncover its hidden paten. The Utility of its tools enable researchers to use it in many applications and to data irrelative of its size. In this paper the Naïve Bayes Classifier and Rule Induction, were used as a data mining tools, to classify person with, or without, Osteoporosis, and to detect the main causes that leads to Osteoporosis. Data was collected from a sample of patient, from Al-Salam and Al-Jamhori Hospitals in Mosul City. Direct interview to those patient were used to collect information about the history and the stage of the cases. Based on this data a Model for the Osteoporosis Stages was derived and software was designed, to be used by specialist in the diagnosis and treatment of the disease. The study reached some conclusion and suggestion

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Fracture Risk After Bilateral Oophorectomy in Elderly Women

Cited by 113 publications

References 60 publications

Non-cancer endpoints in BRCA1/2 carriers after risk-reducing salpingo-oophorectomy

Non-cancer endpoints in BRCA1/2 carriers after risk-reducing salpingo-oophorectomy

Influence of hysterectomy on long-term fracture risk

Design Advance Database Supported with some of Data Mining Ensemble for Early Deduction of Osteoporosis

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