Fracture risk and bone density of peri- and early postmenopausal women with uterine leiomyomas

Randell, Kaisa; Honkanen, Risto; Tuppurainen, Marjo; Kröger, Heikki; Jurvelin, Jukka S.; Saarikoski, Seppo

doi:10.1016/j.maturitas.2005.06.002

Cited by 6 publications

(9 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results were consistent with that of a retrospective ana lysis conducted by Rozenburg [10], who found that subjects with ULM had significantly higher BMD in the vertebra compared with the reference population. Our investigation is also in strong agreement with that of Randell et al [9], who have concluded that peri-and early postmenopausal women with a history of leiomyoma seem to have higher BMD and less fractures compared with those without leiomyoma. However, this relationship, has not been described in African-American women until now.…”

Section: Discussionsupporting

confidence: 93%

Bone Mineral Density in African–American Women with Symptomatic Uterine Leiomyoma

Muneyyirci-Delale

Nessim

Mathur

et al. 2010

Womens Health (Lond Engl)

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

Bone Mineral Density in African–American Women with Symptomatic Uterine Leiomyoma

Muneyyirci-Delale

Nessim

Mathur

et al. 2010

Womens Health (Lond Engl)

View full text Add to dashboard Cite

show abstract

“…Whether other common indications for hysterectomy such as fibroids or endometriosis also could be associated with increased risk for early menopause is unknown. Indirect evidence based on decreased risk of fracture or higher bone mineral density among women with a history of fibroids suggests that estrogen levels and by extension, ovarian function, may be higher among women with fibroids,(34, 35) which would argue against women with fibroids being at higher risk for early ovarian failure.…”

Section: Discussionmentioning

confidence: 99%

Effect of Hysterectomy With Ovarian Preservation on Ovarian Function

Moorman

Myers

Schildkraut

et al. 2011

Obstetrics &Amp; Gynecology

197

136

View full text Add to dashboard Cite

Objective To prospectively estimate the risk for earlier ovarian failure among women undergoing hysterectomy with ovarian preservation, as compared to women of similar age without hysterectomy. Methods A prospective cohort study was conducted among women aged 30 to 47 years undergoing hysterectomy without bilateral oophorectomy (n=406) and women with intact uteri (n=465). Blood samples and questionnaire data were obtained at baseline and annually for up to 5 years. Hazard ratios (HR) for ovarian failure, defined as follicle-stimulating hormone (FSH) levels 40 IU/L or higher, were calculated using Cox proportional hazards models. Results Ovarian failure occurred among 60 of the women with hysterectomy and 46 of the control women. Women undergoing hysterectomy were at nearly a twofold increased risk for ovarian failure as compared to women with intact uteri (HR=1.92, 95% confidence interval (CI) 1.29 – 2.86). The proportional hazards model further estimated that 14.8% of women with hysterectomy experienced ovarian failure after four years of follow-up compared to 8.0% of the control women. Risk for ovarian failure was greater for women who had a unilateral oophorectomy along with their hysterectomy (HR=2.93, 95% CI 1.57 – 5.49), but also was significantly increased for women who retained both ovaries (HR=1.74, 95% CI 1.14 – 2.65). Conclusions Increased risk of earlier ovarian failure is a possible consequence of premenopausal hysterectomy. While it is unresolved whether it is the surgery itself or the underlying condition leading to hysterectomy that is the cause of earlier ovarian failure, physicians and patients should take into account this possible sequela when considering options for treatment of benign conditions of the uterus.

show abstract

“…They also postulated that the presence of fibroids may indicate more oestrogen exposure than controls without fibroids. They also found that there were less fractures in the hysterectomized patients compared with those without leiomyomas (18).…”

Section: Resultsmentioning

confidence: 93%

Bone Mineral Density in Jamaican Black Women after Hysterectomy and Bilateral Oophorectomy: An Observational Study

et al. 2014

View full text Add to dashboard Cite

Objective: To see if black Jamaican postmenopausal women who had hysterectomy were at increased risk of osteoporosis. To assess the risk of osteoporosis in hysterectomized Jamaican postmenopausal patients. Method: We reviewed 809 women (403 hysterectomized and 406 controls) for cardiovascular disease risk. We did a demographic history and examination looking at blood pressure, waist hip ratio and body mass index and investigations done included fasting blood glucose and total and high density lipoprotein (HDL) cholesterol. We also measured bone density at the heel in all women using the Achilles ultrasound bone densitometer looking at T-score and Z-score. Results: There was a significant association of hysterectomy status and bone mineral density (BMD) status with a smaller than expected proportion of women with osteoporosis in the hysterectomy group (χ 2 = 18.4; p = 0.001). The mean T-score was significantly higher in the hysterectomized women, adjusting for age, waist circumference and sociodemographic factors. The relationship between the various predictors and BMD was explored by stepwise regression modelling. The factors that were significantly related to low BMD were hysterectomy status, age, waist circumference and being employed. Conclusion: Hysterectomy was not found to be a significant risk factor for osteoporosis. The osteoporosis risk among menopausal women in Jamaica appears to be due to other risk factors which probably existed prior to the operation.

show abstract

Fracture risk and bone density of peri- and early postmenopausal women with uterine leiomyomas

Cited by 6 publications

References 27 publications

Bone Mineral Density in African–American Women with Symptomatic Uterine Leiomyoma

Bone Mineral Density in African–American Women with Symptomatic Uterine Leiomyoma

Effect of Hysterectomy With Ovarian Preservation on Ovarian Function

Bone Mineral Density in Jamaican Black Women after Hysterectomy and Bilateral Oophorectomy: An Observational Study

Contact Info

Product

Resources

About