Fracture risk and fracture prevalence in women from outpatient osteoporosis clinic and subjects from population-based sample: A comparison between GO Study and RAC-OST-POL cohorts

Pluskiewicz, Wojciech; Adamczyk, Piotr; Drozdzowska, Bogna

doi:10.17219/acem/152736

Cited by 2 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The developed world has seen a sharp increase in the rate and prevalence of diseases associated with the localized and general loss of bone mass. Numerous studies have reported that many entities and medications are associated with this loss [1][2][3][4][5][6], which together with an increasingly sedentary lifestyle have a profound impact on bone metabolism [7]. Serious bone lesions are difficult to redress through autologous processes, which means that therapeutic procedures need to be used instead, but these are still limited [8].…”

Section: Introductionmentioning

confidence: 99%

Bone Regeneration with Stem Cells from Dental Pulp in a Rat Experimental Model

Hamad-Alrashid,

Muntión,

Sánchez-Guijo

et al. 2024

Preprint

View full text Add to dashboard Cite

The increase in the rate and prevalence of diseases associated with the localized and general loss of bone mass calls for an investigation into therapeutic alternatives that largely involve the de-velopment of new biomaterials and cell therapy, converting tissue bioengineering into a prom-ising option. An experimental model of a critical mandibular lesion in rats has been used to study bone re-generation by treating the ostectomy with the biomaterials Evolution® and Gen-Os® (OsteoBiol®, Italy) combined, or not, with dental pulp stem cells (DP-MSC). The results obtained through the Micro-CT and histological study reveal the almost complete re-covery of the lesion in the group with DP-MSC. These results are supported by increases in endoglin, TGF-β, protocollagen I, parathormone, and calcitonin, generating an environment of bone generation and development when combining Evolution® and Gen-Os® (OsteoBiol®, Italy) with DP-MSC. These promising results confirm the transcendental role of DP-MSC in combina-tion with osteogenic biomaterials for bone regeneration, and warrant further studies, including its assessment in clinical trials.

show abstract

Section: Introductionmentioning

confidence: 99%

Bone Regeneration with Stem Cells from Dental Pulp in a Rat Experimental Model

Hamad-Alrashid,

Muntión,

Sánchez-Guijo

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Bone Regeneration with Dental Pulp Stem Cells in an Experimental Model

Hamad-Alrashid,

Muntión,

Sánchez-Guijo

et al. 2024

JPM

View full text Add to dashboard Cite

Background/Objectives: The therapeutic approach to bone mass loss and bone’s limited self-regeneration is a major focus of research, emphasizing new biomaterials and cell therapy. Tissue bioengineering emerges as a potential alternative to conventional treatments. In this study, an experimental model of a critical bone lesion in rats was used to investigate bone regeneration by treating the defect with biomaterials Evolution® and Gen-Os® (OsteoBiol®, Turín, Italy), with or without mesenchymal stromal cells from dental pulp (DP-MSCs). Methods: Forty-six adult male Wistar rats were subjected to a 5-mm critical bone defect in the right mandible, which does not regenerate without intervention. The rats were randomly assigned to a Simulated Group, Control Group, or two Study Groups (using Evolution®, Gen-Os®, and DP-MSCs). The specimens were euthanized at three or six months, and radiological, histological, and ELISA tests were conducted to assess bone regeneration. Results: The radiological results showed that the DP-MSC group achieved uniform radiopacity and continuity in the bone edge, with near-complete structural defect restitution. Histologically, full bone regeneration was observed, with well-organized, vascularized lamellar bone and no lesion edges. These findings were supported by increases in endoglin, transforming growth factor-beta 1 (TGF-β1), protocollagen, parathormone, and calcitonin, indicating a conducive environment for bone regeneration. Conclusions: The use of DP-MSCs combined with biomaterials with appropriate three-dimensional matrices is a promising therapeutic option for further exploration.

show abstract

Fracture risk and fracture prevalence in women from outpatient osteoporosis clinic and subjects from population-based sample: A comparison between GO Study and RAC-OST-POL cohorts

Abstract: Pluskiewicz W, Adamczyk P, Drozdzowska B. Fracture risk and fracture prevalence in women from outpatient osteoporosis clinic and subjects from population-based sample: A comparison between GO Study and RAC-OST-POL cohorts [published online as ahead of print on September 22, 2022].

Cited by 2 publications

References 18 publications

Bone Regeneration with Stem Cells from Dental Pulp in a Rat Experimental Model

Bone Regeneration with Stem Cells from Dental Pulp in a Rat Experimental Model

Bone Regeneration with Dental Pulp Stem Cells in an Experimental Model

Contact Info

Product

Resources

About