Fractures of the Femur in Pagetʼs Disease of Bone in Australia

Subtrochanteric femoral stress fracture with features of atypical femoral fracture in patient with Paget�s disease: a case report

“…Because patients with Paget disease are commonly treated with long-term bisphosphonate treatment (13), some Authors included patients with Paget disease to estimate the incidence of AFF in patients on bisphosphonate (14). However, subtrochanteric transverse insufficiency fractures (which may be complete or incomplete) are well-documented complications of Paget's disease in the femur and typically begin on its lateral aspect (15,16). Although fractures in patients with Paget's disease showed usually stress fracture, its pathophysiology might be distinctively apart from bisphosphonate-associated insufficiency fracture (17).…”

Complications of Paget’s Disease of Bone

“…Large series reported include those by Lake [1958], Nicholas and Killoran [1965], Barry [1967] and Grundy [1970], Apart from the common vertebral lesions other bones liable to fracture are the tibia, humerus, and pelvis. Fractures tend to occur on the con vexity of a curved and diseased bone, and are often preceded by linear stress fractures, which may be symptomless.…”

“…Although they may follow trauma, this is often trivial, and in about one-quarter of the cases of femoral fracture there is no history of injury, the leg merely 'giving way' during normal activity [Grundy, 1970], It has been assumed that the abnormal trabecular pattern fails to provide the normal mechanical resistance to minor stress. The most common site for fe moral fracture is the subtrochanteric region, and the mid-shaft and femoral neck are other vulnerable areas [Barry, 1967;Grundy, 1970], It seems probable but not certain that fractures of the femur are more common in Paget's disease than in the normal popula tion. Healing is unpredictable, and although rapid in some cases, permanent non-union is troublesome in others, especially those in- volving the femoral neck.…”

“…arises at the site of pre vious fracture. It is more certain that a patho logical fracture can be the presenting feature of the sarcoma [Barry, 1967].…”

Valoración del riesgo cardiovascular en los pacientes con enfermedad ósea de Paget (EOP) en Salamanca

“…Fracturas, ya que el hueso pagético transmite mal las cargas. Las fracturas se suelen localizar en áreas expuestas a mayor presión mecánica -convexidad externa del fémur y anterior de la tibia o pelvis y en la parte central de las vértebras- 28 .…”