Fradiamine A, a new siderophore from the deep-sea actinomycete Streptomyces fradiae MM456M-mF7

Takehana, Yasuhiro; Umekita, Maya; Hatano, Masaki; Kato, Chiaki; Sawa, Ryûichi; Igarashi, Masayuki

doi:10.1038/ja.2017.26

Cited by 25 publications

(14 citation statements)

References 25 publications

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“…Fradiamine A (2) and B are natural siderophores produced by the deep-sea Streptomyces fradiae MM456M and have shown moderate antibiotic activity against Clostridium difficile [45]. Other examples of siderophores isolated from marine environment are the catechol-type siderophore, streptobactin (5) and benarthin (6), isolated from Streptomyces sp.…”

Section: Streptomyces: a Natural Source Of Siderophores Among Bacteriamentioning

confidence: 99%

Biotechnological Potential of Streptomyces Siderophores as New Antibiotics

Terra¹,

Dyson²,

Ratcliffe³

et al. 2021

CMC

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Background: Siderophores are small molecule iron-chelators produced by microorganisms and plants growing mostly under low iron conditions. Siderophores allow iron capture and transport through cell membranes into the cytoplasm, where iron is released for use in biological processes. These bacterial iron uptake systems can be used for antibiotic conjugation or as targets for killing pathogenic bacteria. Siderophores have been explored recently because of their potential applications in environmental and therapeutic research. They are present in Streptomyces, Gram-positive bacteria that are an important source for discovering new siderophores. Objective: This review summarizes siderophore molecules produced by the genus Streptomyces emphasizing their potential as biotechnological producers and also illustrating genomic tools for discovering siderophores useful for treating bacterial infections. Methods: The literature search was performed using PUBMED and MEDLINE databases with keywords siderophore, secondary metabolites, Trojan horse strategy, sideromycin and Streptomyces. The literature research focused on bibliographic databases including all siderophores identified in the genus Streptomyces. In addition, reference genomes of Streptomyces from GenBank were used to identify siderophore biosynthetic gene clusters by using the antiSMASH platform. Results: This review has highlighted some of the many siderophore molecules produced by Streptomyces, illustrating the diversity of their chemical structures and wide spectrum of bioactivities against pathogenic bacteria. Furthermore, the possibility of using siderophores conjugated with antibiotics could be an alternative to overcome bacterial resistance to drugs and could improve their therapeutic efficacy. Conclusion: This review confirms the importance of Streptomyces as a rich source of siderophores, and underlines their potential as antibacterial agents.

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Section: Streptomyces: a Natural Source Of Siderophores Among Bacteriamentioning

confidence: 99%

Biotechnological Potential of Streptomyces Siderophores as New Antibiotics

Terra¹,

Dyson²,

Ratcliffe³

et al. 2021

CMC

View full text Add to dashboard Cite

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“…A new siderophore and its derivative, designated as fradiamines A (24) and B (25), were recently found to be produced by Streptomyces fradiae MM456M-mF7, isolated from the deep-sea sediment sample collected at a depth of 806 m in the Sagami Bay, Japan. Fradiamines A and B displayed moderate antibacterial activity against Clostridium difficile BAA-1382 with IC 50 values of 32 and 8 μ g·ml −1 , respectively [82].…”

Section: Novel Antibacterial and Anticancer Compounds From Culturmentioning

confidence: 99%

Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?

Sivalingam

Hong

Poté

et al. 2019

International Journal of Microbiology

125

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Antimicrobial resistance (AR) is recognized as one of the greatest threats to public health and in global concern. Consequently, the increased morbidity and mortality, which are associated with multidrug resistance bacteria, urgently require the discovery of novel and more efficient drugs. Conversely, cancer is a growing complex human disease that demands new drugs with no or fewer side effects. Most of the drugs currently used in the health care systems were of Streptomyces origin or their synthetic forms. Natural product researches from Streptomyces have been genuinely spectacular over the recent years from extreme environments. It is because of technical advances in isolation, fermentation, spectroscopy, and genomic studies which led to the efficient recovering of Streptomyces and their new chemical compounds with distinct activities. Expanding the use of the last line of antibiotics and demand for new drugs will continue to play an essential role for the potent Streptomyces from previously unexplored environmental sources. In this context, deep-sea, desert, cryo, and volcanic environments have proven to be a unique habitat of more extreme, and of their adaptation to extreme living, environments attribute to novel antibiotics. Extreme Streptomyces have been an excellent source of a new class of compounds which include alkaloids, angucycline, macrolide, and peptides. This review covers novel drug leads with antibacterial and cytotoxic activities isolated from deep-sea, desert, cryo, and volcanic environment Streptomyces from 2009 to 2019. The structure and chemical classes of the compounds, their relevant bioactivities, and the sources of organisms are presented.

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“…It has, however, been found that a number of earlier reported NPs attributed to sponges are in fact biosynthesized by their endosymbionts [162], many of which are Actinomycetes. Through the utilization of metabolomics along with other omics tools, marine Actinomycetes have been explored and profiled [163][164][165][166][167] while many new potential drugs [112,113,117,160,162,[168][169][170][171][172][173][174] and agrochemicals [175] have been recently described. For the purpose of this literature appraisal, three research papers were selected and analyzed to assess the application of metabolomics to current drug discovery programs, with a particular focus on novel antibiotics isolated from marine Streptomyces.…”

Section: Marine Bacteriamentioning

confidence: 99%

Metabolomic tools used in marine natural product drug discovery

Stuart

Welsh

Walker

et al. 2020

Expert Opinion on Drug Discovery

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The marine environment is a very promising resource for natural product research, with many of these reaching the market as new drugs, especially in the field of cancer therapy as well as the drug discovery pipeline for new antimicrobials. Exploitation for bioactive marine compounds with unique structures and novel bioactivity such as the isoquinoline alkaloid; trabectedin, the polyether macrolide; halichondrin B, and the peptide; dolastatin 10, requires the use of analytical techniques, which can generate unbiased, quantitative and qualitative data to benefit the biodiscovery process. Metabolomics has shown to bridge this understanding and facilitate the development of new potential drugs from marine sources and particularly their microbial symbionts. Areas covered: In this review, articles on applied secondary metabolomics ranging from 1990-2018 as well as to the last quarter of 2019 were probed to investigate the impact of metabolomics on drug discovery for new antibiotics and cancer treatment. Expert opinion: The current literature review highlighted the effectiveness of metabolomics in the study of targeting biologically active secondary metabolites from marine sources for optimized discovery of potential new natural products to be made accessible to a R&D pipeline.

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Fradiamine A, a new siderophore from the deep-sea actinomycete Streptomyces fradiae MM456M-mF7

Cited by 25 publications

References 25 publications

Biotechnological Potential of Streptomyces Siderophores as New Antibiotics

Biotechnological Potential of Streptomyces Siderophores as New Antibiotics

Extreme Environment Streptomyces: Potential Sources for New Antibacterial and Anticancer Drug Leads?

Metabolomic tools used in marine natural product drug discovery

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