Mechanical penetrations, as important pressure pipelines penetrating the reactor compartment, withstand high temperatures and pressures. The current complete design and verification process for mechanical penetrations. This article focuses on the problem of stress concentration and easy damage of the penetration components in the reactor compartment under high temperature and high pressure environment. Combining with the existing regulations of nuclear power plants and ships, finite element analysis method is used to analyze the stress of the penetration components under specific high temperature and high pressure and ship ultimate load coupling. At the same time, based on the simulation analysis results, the structural dimensions of the penetration components are optimized, and a mechanical penetration verification process is designed. The coupled thermal stress results of the penetration indicate that the stress of the penetration is too large at the tail of the sleeve, with the values of primary film stress Pm and primary bending stress Pb being 228.2 and 275.91 MPa, respectively. From this, it can be seemed that there is obvious stress concentration at the junction of the support ring and sleeve, as well as at the transition point of the insulation layer, which is the weakest area of the penetration.