Fragment-based modification of 2,4-diarylaminopyrimidine derivatives as ALK and ROS1 dual inhibitors to overcome secondary mutants

Visible Light-Promoted Synthesis of β-Keto Sulfoximines from N-Tosyl-Protected Sulfoximidoyl Chlorides

“…Conversions of alkynes into β-substituted ketones have attracted a great deal of attention in recent years . In the list of products, β-keto sulfones are of particular interest as they have found numerous applications in the construction of natural and pharmaceutically relevant products . In 2013, Lei and co-workers accessed β-keto sulfones by aerobic difunctionalizations of terminal alkynes, and a careful mechanistic analysis revealed that the transformation proceeded via radicals (Scheme , path a) .…”